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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Cash flows from operating activities:    
Net loss $ (89,868) $ (33,026)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 506 417
Amortization of debt discount and debt issuance costs 2,229 625
Change in deferred taxes 25,870 (6,228)
Stock-based compensation expense 3,163 3,729
Gain from release of certain liabilities (33) (166)
Other adjustments 1,239 757
Net changes in assets and liabilities    
Prepaid expenses and other current assets 13,305 (3,106)
Research and development tax credit receivable 30 3,078
Accounts payable & other current liabilities (4,457) 176
Accrued expenses 2,559 1,199
Other assets and liabilities (2,678) (1,021)
Net cash used in operating activities (48,135) (33,566)
Cash flows from investing activities:    
Purchases of property and equipment 0 (26)
Proceeds from the disposition of the hospital products 0 16,500
Proceeds from sales of marketable securities 56,501 66,213
Purchases of marketable securities (2,202) (53,372)
Net cash provided by investing activities 54,299 29,315
Cash flows from financing activities:    
Payments for debt issuance costs (4,803) 0
Proceeds from stock option exercises and employee share purchase plan 2,009 149
Net cash (used in) provided by financing activities (2,794) 149
Effect of foreign currency exchange rate changes on cash and cash equivalents 50 (478)
Net change in cash and cash equivalents 3,420 (4,580)
Cash and cash equivalents at January 1, 50,708 71,722
Cash and cash equivalents at June 30, 54,128 67,142
Supplemental disclosures of cash flow information:    
Interest paid 6,455 3,234
Income taxes (refund) paid $ (14,096) $ 7