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v3.23.1

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021
Cash flows from operating activities: |  |
Net loss | $ (137,464) | $ (77,329)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 1,493 | 815
Amortization of debt discount and debt issuance costs | 6,052 | 1,248
Changes in deferred tax | 26,025 | (15,666)
Share-based compensation expense | 7,013 | 8,872
Other adjustments | 2,042 | 1,055
Net changes in assets and liabilities |  |
Prepaid expenses and other current assets | 30,815 | (439)
Research and development tax credit receivable | 30 | 2,796
Accounts payable & other current liabilities | (3,108) | 4,232
Accrued expenses | 227 | 895
Other assets and liabilities | (3,429) | (3,789)
Net cash used in operating activities | (70,304) | (77,310)
Cash flows from investing activities: |  |
Purchases of property and equipment | (716) | (26)
Proceeds from the disposition of the Hospital Products | 0 | 16,500
Proceeds from sales of marketable securities | 83,828 | 102,224
Purchases of marketable securities | (3,414) | (61,769)
Net cash provided by investing activities | 79,698 | 56,929
Cash flows from financing activities: |  |
Payments for debt issuance costs | (4,804) | 0
Payments for extinguishment of February 2023 Notes | (8,653) | 0
Proceeds from stock option exercises and employee share purchase plan | 2,682 | 263
Proceeds from issuance of shares off the at-the-market offering program | 25,318 | 0
Net cash provided by financing activities | 14,543 | 263
Effect of foreign currency exchange rate changes on cash and cash equivalents | (664) | (896)
Net change in cash and cash equivalents | 23,273 | (21,014)
Cash and cash equivalents at January 1 | 50,708 | 71,722
Cash and cash equivalents at December 31 | 73,981 | 50,708
Supplemental disclosures of cash flow information: |  |
Income taxes (refunded) paid, net | (29,058) | 76
Interest paid | $ 9,660 | $ 6,469

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