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v3.23.1

Subsequent Events (Details) - USD ($) $ / shares in Units, shares in Thousands, $ in Thousands |  |  |  |  | 3 Months Ended |
--- | --- | --- | --- | --- | --- | ---
May 01, 2023 | Apr. 04, 2023 | Apr. 03, 2023 | Apr. 03, 2023 | Mar. 31, 2023 | Mar. 31, 2023 | Mar. 31, 2022 | Dec. 31, 2022
Subsequent Event [Line Items] |  |  |  |  |  |  |  |
Ordinary shares, nominal value (in usd per share) |  |  |  |  | $ 0.01 | $ 0.01 |  | $ 0.01
Proceeds from issuance of shares off the at-the-market offering program |  |  |  |  |  | $ 11,913 | $ 0 |
Public Stock Offering, Tranche One |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |
Aggregate net proceeds from stock offering |  |  |  |  | $ 40,000 |  |  |
Subsequent Event |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |
Term of orphan drug exclusivity | 7 years |  |  |  |  |  |  |
Subsequent Event | Series B Preferred Stock |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |
Shares sold in offering |  |  |  | 4,706 |  |  |  |
Subsequent Event | American Depositary Shares |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |
Shares sold in offering |  |  |  | 12,205 |  |  |  |
Subsequent Event | Public Stock Offering |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |
Proceeds from issuance of shares off the at-the-market offering program |  |  | $ 135,125 | $ 135,125 |  |  |  |
Subsequent Event | Public Stock Offering, Tranche Two |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |
Aggregate net proceeds from stock offering |  |  |  | 95,125 |  |  |  |
4.50% Exchangeable Senior Notes Due October 2023 |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |
Interest rate |  |  |  |  | 4.50% | 4.50% |  |
4.50% Exchangeable Senior Notes Due October 2023 | Senior Notes |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |
Long-term debt |  |  |  |  | $ 117,375 | $ 117,375 |  | $ 117,375
Interest rate |  |  |  |  | 4.50% | 4.50% |  |
4.50% Exchangeable Senior Notes Due October 2023 | Senior Notes | Subsequent Event |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |
Debt exchanged |  | $ 96,188 |  | 96,188 |  |  |  |
Long-term debt |  | $ 21,187 |  |  |  |  |  |
April 2027 Notes | Subsequent Event |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |
Interest rate |  | 6.00% |  |  |  |  |  |
April 2027 Notes | Senior Notes | Subsequent Event |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |
Long-term debt |  | $ 106,268 | $ 106,268 | $ 106,268 |  |  |  |

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