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v3.23.1

Summary of Significant Accounting Policies - Narrative (Details) - USD ($) $ / shares in Units, shares in Thousands, $ in Thousands |  |  |  |  |  |  | 3 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
May 01, 2023 | Apr. 04, 2023 | Apr. 03, 2023 | Apr. 03, 2023 | Mar. 31, 2023 | Mar. 29, 2023 | Feb. 05, 2020 | Mar. 31, 2023 | Mar. 31, 2022 | Dec. 31, 2022 | Aug. 31, 2022 | Feb. 14, 2020
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Cash and cash equivalents |  |  |  |  | $ 83,391 |  |  | $ 83,391 |  | $ 73,981 |  |
Marketable securities |  |  |  |  | $ 17,532 |  |  | $ 17,532 |  | $ 22,518 |  |
Quarterly net revenue target for royalty financing |  |  |  |  |  | $ 25,000 |  |  |  |  |  |
Ordinary shares, nominal value (in usd per share) |  |  |  |  | $ 0.01 |  |  | $ 0.01 |  | $ 0.01 |  |
Proceeds from issuance of shares off the at-the-market offering program |  |  |  |  |  |  |  | $ 11,913 | $ 0 |  |  |
Issuance of common stock under at-the-market offering program, net of issuance costs |  |  |  |  |  |  |  | $ 11,913 |  |  |  |
Ordinary shares |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
February 2020 private placement (in shares) |  |  |  |  |  |  |  | 1,564 |  |  |  |
Issuance of common stock under at-the-market offering program, net of issuance costs |  |  |  |  |  |  |  | $ 16 |  |  |  |
Forecast |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Royalty financing | $ 30,000 |  |  |  |  |  |  |  |  |  |  |
Subsequent Event |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Term of orphan drug exclusivity | 7 years |  |  |  |  |  |  |  |  |  |  |
Public Stock Offering | Subsequent Event |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from issuance of shares off the at-the-market offering program |  |  | $ 135,125 | $ 135,125 |  |  |  |  |  |  |  |
Public Stock Offering, Tranche One |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from stock offering |  |  |  |  | $ 40,000 |  |  |  |  |  |  |
Public Stock Offering, Tranche Two | Subsequent Event |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from stock offering |  |  |  | 95,125 |  |  |  |  |  |  |  |
2020 Shelf Registration Statement |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Sales agent commission, as a percent of aggregate gross sales proceeds |  |  |  |  |  |  | 3.00% |  |  |  |  |
Maximum aggregate offering price of ADSs under shelf registration |  |  |  |  |  |  |  |  |  |  |  | $ 50,000
2022 Shelf Registration Statement |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Maximum aggregate offering price of ADSs under shelf registration |  |  |  |  |  |  |  |  |  |  | $ 100,000 |
At-The-Market Offering Program |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Remaining authorized aggregate offering price under shelf registration |  |  |  |  | $ 96,064 |  |  | $ 96,064 |  |  |  |
Maximum |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Royalty financing |  |  |  |  |  | $ 75,000 |  |  |  |  |  |
4.50% Exchangeable Senior Notes Due October 2023 |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Interest rate |  |  |  |  | 4.50% |  |  | 4.50% |  |  |  |
4.50% Exchangeable Senior Notes Due October 2023 | Senior Notes |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Long-term debt |  |  |  |  | $ 117,375 |  |  | $ 117,375 |  | $ 117,375 |  |
Interest rate |  |  |  |  | 4.50% |  |  | 4.50% |  |  |  |
4.50% Exchangeable Senior Notes Due October 2023 | Senior Notes | Subsequent Event |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Long-term debt |  | $ 21,187 |  |  |  |  |  |  |  |  |  |
Debt exchanged |  | $ 96,188 |  | 96,188 |  |  |  |  |  |  |  |
April 2027 Notes | Subsequent Event |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Interest rate |  | 6.00% |  |  |  |  |  |  |  |  |  |
April 2027 Notes | Senior Notes | Subsequent Event |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Long-term debt |  | $ 106,268 | $ 106,268 | $ 106,268 |  |  |  |  |  |  |  |

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