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Subsequent Events (Details) - USD ($) $ / shares in Units, shares in Thousands, $ in Thousands						3 Months Ended
	May 01, 2023	Apr. 04, 2023	Apr. 03, 2023	Apr. 03, 2023	Mar. 31, 2023	Mar. 31, 2023	Mar. 31, 2022	Dec. 31, 2022
Subsequent Event [Line Items]
Ordinary shares, nominal value (in usd per share)					$ 0.01	$ 0.01		$ 0.01
Proceeds from issuance of shares off the at-the-market offering program						$ 11,913	$ 0
Public Stock Offering, Tranche One
Subsequent Event [Line Items]
Aggregate net proceeds from stock offering					$ 40,000
Subsequent Event
Subsequent Event [Line Items]
Term of orphan drug exclusivity	7 years
Subsequent Event | Series B Preferred Stock
Subsequent Event [Line Items]
Shares sold in offering				4,706
Subsequent Event | American Depositary Shares
Subsequent Event [Line Items]
Shares sold in offering				12,205
Subsequent Event | Public Stock Offering
Subsequent Event [Line Items]
Proceeds from issuance of shares off the at-the-market offering program			$ 135,125	$ 135,125
Subsequent Event | Public Stock Offering, Tranche Two
Subsequent Event [Line Items]
Aggregate net proceeds from stock offering				95,125
4.50% Exchangeable Senior Notes Due October 2023
Subsequent Event [Line Items]
Interest rate					4.50%	4.50%
4.50% Exchangeable Senior Notes Due October 2023 | Senior Notes
Subsequent Event [Line Items]
Long-term debt					$ 117,375	$ 117,375		$ 117,375
Interest rate					4.50%	4.50%
4.50% Exchangeable Senior Notes Due October 2023 | Senior Notes | Subsequent Event
Subsequent Event [Line Items]
Debt exchanged		$ 96,188		96,188
Long-term debt		$ 21,187
April 2027 Notes | Subsequent Event
Subsequent Event [Line Items]
Interest rate		6.00%
April 2027 Notes | Senior Notes | Subsequent Event
Subsequent Event [Line Items]
Long-term debt		$ 106,268	$ 106,268	$ 106,268

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