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CONDENSED CONSOLIDATED STATEMENTS OF SHAREHOLDERS’ (DEFICIT) EQUITY - USD ($)
shares in Thousands, $ in Thousands
Total
Ordinary shares
Preferred shares
Additional paid-in capital
Accumulated deficit
Accumulated other comprehensive (loss) income
Beginning balance (in shares) at Dec. 31, 2021   58,620 488      
Beginning balance at Dec. 31, 2021 $ 78,244 $ 586 $ 5 $ 549,349 $ (447,756) $ (23,940)
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Net loss (26,424)       (26,424)  
Other comprehensive income (1,102)         (1,102)
Exercise of stock options (in shares)   275        
Exercise of stock options 1,906 $ 3   1,903    
Vesting of restricted shares (in shares)   119        
Vesting of restricted shares 0 $ 1   (1)    
Employee share purchase plan share issuance (in shares)   18        
Employee share purchase plan share issuance 103     103    
Stock-based compensation expense 2,505     2,505    
Ending balance (in shares) at Mar. 31, 2022   59,032 488      
Ending balance at Mar. 31, 2022 55,232 $ 590 $ 5 553,859 (474,180) (25,042)
Beginning balance (in shares) at Dec. 31, 2022   62,878 488      
Beginning balance at Dec. 31, 2022 (21,145) $ 628 $ 5 589,783 (585,220) (26,341)
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Net loss (30,784)       (30,784)  
Other comprehensive income 315         315
Issuance of common stock under at-the-market offering program, net of issuance costs (in shares)   1,564        
Issuance of common stock under at-the-market offering program, net of issuance costs 11,913 $ 16   11,897    
Amortization of deferred issuance costs (16)     (16)    
Vesting of restricted shares (in shares)   22        
Vesting of restricted shares 0          
Employee share purchase plan share issuance (in shares)   14        
Employee share purchase plan share issuance 29     29    
Stock-based compensation expense 1,522     1,522    
Ending balance (in shares) at Mar. 31, 2023   64,478 488      
Ending balance at Mar. 31, 2023 $ (38,166) $ 644 $ 5 $ 603,215 $ (616,004) $ (26,026)