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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2023
Mar. 31, 2022
Cash flows from operating activities:    
Net loss $ (30,784) $ (26,424)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 588 259
Amortization of debt discount and debt issuance costs 1,873 312
Changes in deferred taxes 0 (4,323)
Share-based compensation expense 1,522 2,505
Other adjustments (1) 669
Net changes in assets and liabilities    
Prepaid expenses and other current assets (4,131) (2,058)
Research and development tax credit receivable 0 (19)
Accounts payable & other current liabilities 468 (5,613)
Accrued expenses 348 2,314
Other assets and liabilities (116) (1,667)
Net cash used in operating activities (30,233) (34,045)
Cash flows from investing activities:    
Proceeds from sales of marketable securities 15,295 44,341
Purchases of marketable securities (10,229) (2,090)
Net cash provided by investing activities 5,066 42,251
Cash flows from financing activities:    
Proceeds received in advance of Series B Preferred Shares Issuance 40,000 0
Payments for February 2023 Notes (17,500) 0
Proceeds from issuance of shares off the at-the-market offering program 11,913 0
Proceeds from stock option exercises and employee share purchase plan 29 2,009
Net cash provided by financing activities 34,442 2,009
Effect of foreign currency exchange rate changes on cash and cash equivalents 135 (50)
Net change in cash and cash equivalents 9,410 10,165
Cash and cash equivalents at January 1, 73,981 50,708
Cash and cash equivalents at March 31, 83,391 60,873
Supplemental disclosures of cash flow information:    
Interest paid 3,050 5,531
Income taxes paid $ 0 $ 0