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v3.23.2

Summary of Significant Accounting Policies - Narrative (Details) - USD ($) $ / shares in Units, $ in Thousands |  |  |  |  |  |  |  |  | 6 Months Ended |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Aug. 01, 2023 | May 31, 2023 | May 01, 2023 | Apr. 04, 2023 | Apr. 03, 2023 | Mar. 29, 2023 | Feb. 05, 2020 | Feb. 16, 2018 | Jun. 30, 2023 | Mar. 31, 2023 | Dec. 31, 2022 | Aug. 31, 2022 | Feb. 14, 2020
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Term of orphan drug exclusivity |  |  | 7 years |  |  |  |  |  |  |  |  |  |
Quarterly net revenue target for royalty financing |  |  |  |  |  | $ 25,000 |  |  |  |  |  |  |
Ordinary shares, nominal value (in dollars per share) |  | $ 0.01 |  |  | $ 0.01 |  |  |  | $ 0.01 |  | $ 0.01 |  |
Aggregate net proceeds from stock offering |  |  |  |  | $ 134,151 |  |  |  |  |  |  |  |
ADSs, conversion ratio |  | 11618.46% |  |  |  |  |  | 9269.56% |  |  |  |  |
Number of ADSs delivered upon conversion (in shares) |  | 12,347 |  |  |  |  |  |  |  |  |  |  |
Aggregate amount of conversion |  | $ 1,470 |  |  |  |  |  |  |  |  |  |  |
Subsequent Event |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty financing | $ 30,000 |  |  |  |  |  |  |  |  |  |  |  |
Ordinary shares |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Shares sold in offering (in shares) |  |  |  |  | 12,205,000 |  |  |  |  |  |  |  |
Series B Non-Voting Convertible Preferred Shares |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Shares sold in offering (in shares) |  |  |  |  | 4,706,000 |  |  |  |  |  |  |  |
2020 Shelf Registration Statement |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Sales agent commission, as a percent of aggregate gross sales proceeds |  |  |  |  |  |  | 3.00% |  |  |  |  |  |
Maximum aggregate offering price of ADSs under shelf registration |  |  |  |  |  |  |  |  |  |  |  |  | $ 50,000
2022 Shelf Registration Statement |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Maximum aggregate offering price of ADSs under shelf registration |  |  |  |  |  |  |  |  |  |  |  | $ 100,000 |
At-The-Market Offering Program |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate net proceeds from stock offering |  |  |  |  |  |  |  |  | $ 11,913 |  |  |  |
Remaining authorized aggregate offering price under shelf registration |  |  |  |  |  |  |  |  | $ 96,064 |  |  |  |
At-The-Market Offering Program | American Depositary Shares |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Shares sold in offering (in shares) |  |  |  |  |  |  |  |  | 1,564,000 |  |  |  |
Maximum |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty financing |  |  |  |  |  | $ 75,000 |  |  |  |  |  |  |
4.50% Exchangeable Senior Notes Due October 2023 |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Interest rate |  |  |  |  |  |  |  |  |  | 4.50% |  |  |
4.50% Exchangeable Senior Notes Due October 2023 | Senior Notes |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Long-term debt |  |  |  | $ 21,187 |  |  |  |  | $ 21,187 | $ 117,375 | $ 117,375 |  |
Interest rate |  |  |  |  |  |  |  |  | 4.50% |  |  |  |
Debt exchanged |  |  |  | $ 96,188 |  |  |  |  |  |  |  |  |
April 2027 Notes |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Interest rate |  |  |  | 6.00% |  |  |  |  |  |  |  |  |
April 2027 Notes | Senior Notes |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Long-term debt |  |  |  | $ 106,268 |  |  |  |  |  |  |  |  |
Debt exchanged |  | $ 106,268 |  |  |  |  |  |  |  |  |  |  |
Aggregate amount of conversion |  |  |  | $ 106,268 |  |  |  |  |  |  |  |  |

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