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CONDENSED CONSOLIDATED STATEMENTS OF SHAREHOLDERS’ EQUITY (DEFICIT) - USD ($) shares in Thousands, $ in Thousands | Total | Ordinary shares | Preferred shares | Additional paid-in capital | Accumulated deficit | Accumulated other comprehensive loss
--- | --- | --- | --- | --- | --- | ---
Beginning balance (in shares) at Dec. 31, 2021 |  | 58,620 | 488 |  |  |
Beginning balance at Dec. 31, 2021 | $ 78,244 | $ 586 | $ 5 | $ 549,349 | $ (447,756) | $ (23,940)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Net loss | (26,424) |  |  |  | (26,424) |
Other comprehensive income (loss) | (1,102) |  |  |  |  | (1,102)
Exercise of stock options (in shares) |  | 275 |  |  |  |
Exercise of stock options | 1,906 | $ 3 |  | 1,903 |  |
Vesting of restricted shares (in shares) |  | 119 |  |  |  |
Vesting of restricted shares | 0 | $ 1 |  | (1) |  |
Employee share purchase plan share issuance (in shares) |  | 18 |  |  |  |
Employee share purchase plan share issuance | 103 |  |  | 103 |  |
Stock-based compensation expense | 2,505 |  |  | 2,505 |  |
Ending balance (in shares) at Mar. 31, 2022 |  | 59,032 | 488 |  |  |
Ending balance at Mar. 31, 2022 | 55,232 | $ 590 | $ 5 | 553,859 | (474,180) | (25,042)
Beginning balance (in shares) at Dec. 31, 2021 |  | 58,620 | 488 |  |  |
Beginning balance at Dec. 31, 2021 | 78,244 | $ 586 | $ 5 | 549,349 | (447,756) | (23,940)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Net loss | (89,868) |  |  |  |  |
Ending balance (in shares) at Jun. 30, 2022 |  | 59,038 | 488 |  |  |
Ending balance at Jun. 30, 2022 | (3,332) | $ 590 | $ 5 | 560,025 | (537,624) | (26,328)
Beginning balance (in shares) at Mar. 31, 2022 |  | 59,032 | 488 |  |  |
Beginning balance at Mar. 31, 2022 | 55,232 | $ 590 | $ 5 | 553,859 | (474,180) | (25,042)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Net loss | (63,444) |  |  |  | (63,444) |
Other comprehensive income (loss) | (1,286) |  |  |  |  | (1,286)
Vesting of restricted shares (in shares) |  | 6 |  |  |  |
Vesting of restricted shares | 0 |  |  |  |  |
Change in fair value of October 2023 Notes conversion feature | 5,508 |  |  | 5,508 |  |
Stock-based compensation expense | 658 |  |  | 658 |  |
Ending balance (in shares) at Jun. 30, 2022 |  | 59,038 | 488 |  |  |
Ending balance at Jun. 30, 2022 | (3,332) | $ 590 | $ 5 | 560,025 | (537,624) | (26,328)
Beginning balance (in shares) at Dec. 31, 2022 |  | 62,878 | 488 |  |  |
Beginning balance at Dec. 31, 2022 | (21,145) | $ 628 | $ 5 | 589,783 | (585,220) | (26,341)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Net loss | (30,784) |  |  |  | (30,784) |
Other comprehensive income (loss) | 315 |  |  |  |  | 315
Issuance of common stock, net of issuance costs (in shares) |  | 1,564 |  |  |  |
Issuance of common stock, net of issuance costs | 11,913 | $ 16 |  | 11,897 |  |
Amortization of deferred issuance costs | (16) |  |  | (16) |  |
Vesting of restricted shares (in shares) |  | 22 |  |  |  |
Vesting of restricted shares | 0 |  |  |  |  |
Employee share purchase plan share issuance (in shares) |  | 14 |  |  |  |
Employee share purchase plan share issuance | 29 |  |  | 29 |  |
Stock-based compensation expense | 1,522 |  |  | 1,522 |  |
Ending balance (in shares) at Mar. 31, 2023 |  | 64,478 | 488 |  |  |
Ending balance at Mar. 31, 2023 | (38,166) | $ 644 | $ 5 | 603,215 | (616,004) | (26,026)
Beginning balance (in shares) at Dec. 31, 2022 |  | 62,878 | 488 |  |  |
Beginning balance at Dec. 31, 2022 | (21,145) | $ 628 | $ 5 | 589,783 | (585,220) | (26,341)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Net loss | (95,216) |  |  |  |  |
Ending balance (in shares) at Jun. 30, 2023 |  | 89,321 | 5,194 |  |  |
Ending balance at Jun. 30, 2023 | 143,192 | $ 893 | $ 52 | 848,626 | (680,436) | (25,943)
Beginning balance (in shares) at Mar. 31, 2023 |  | 64,478 | 488 |  |  |
Beginning balance at Mar. 31, 2023 | (38,166) | $ 644 | $ 5 | 603,215 | (616,004) | (26,026)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Net loss | (64,432) |  |  |  | (64,432) |
Other comprehensive income (loss) | 83 |  |  |  |  | 83
Issuance of common stock, net of issuance costs (in shares) |  | 12,205 | 4,706 |  |  |
Issuance of common stock, net of issuance costs | 134,151 | $ 122 | $ 47 | 133,982 |  |
Mandatory Exchange of April 2027 Note (in shares) |  | 12,347 |  |  |  |
Mandatory Exchange of April 2027 Notes, net of issuance costs | 102,162 | $ 123 |  | 102,039 |  |
Exercise of stock options (in shares) |  | 291 |  |  |  |
Exercise of stock options | 1,750 | $ 4 |  | 1,746 |  |
Stock-based compensation expense | 7,644 |  |  | 7,644 |  |
Ending balance (in shares) at Jun. 30, 2023 |  | 89,321 | 5,194 |  |  |
Ending balance at Jun. 30, 2023 | $ 143,192 | $ 893 | $ 52 | $ 848,626 | $ (680,436) | $ (25,943)

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