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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2023
Jun. 30, 2022
Cash flows from operating activities:    
Net loss $ (95,216) $ (89,868)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 1,189 506
Amortization of debt discount and debt issuance costs 2,460 2,229
Changes in deferred taxes 0 25,870
Share-based compensation expense 9,166 3,163
Loss on extinguishment of debt 13,129 0
Other adjustments 42 1,206
Net changes in assets and liabilities    
Accounts receivable (1,775) 0
Inventories (1,439) 0
Prepaid expenses and other current assets (4,400) 13,305
Research and development tax credit receivable 2,127 30
Accounts payable & other current liabilities 2,470 (4,457)
Accrued expenses 10,246 2,559
Other assets and liabilities (255) (2,678)
Net cash used in operating activities (62,256) (48,135)
Cash flows from investing activities:    
Proceeds from sales of marketable securities 25,618 56,501
Purchases of marketable securities (113,460) (2,202)
Net cash (used in) provided by investing activities (87,842) 54,299
Cash flows from financing activities:    
Payments for February 2023 Notes (17,500) 0
Payments for debt issuance costs (4,357) (4,803)
Proceeds from stock option exercises and employee share purchase plan 1,779 2,009
Net cash provided by (used in) financing activities 125,986 (2,794)
Effect of foreign currency exchange rate changes on cash and cash equivalents 116 50
Net change in cash and cash equivalents (23,996) 3,420
Cash and cash equivalents at January 1, 73,981 50,708
Cash and cash equivalents at June 30, 49,985 54,128
Supplemental disclosures of cash flow information:    
Interest paid 4,520 6,455
Income taxes refund 0 (14,096)
Public Offering    
Cash flows from financing activities:    
Proceeds from issuance of shares, net of issuance costs 134,151 0
At-The-Market Offering Program    
Cash flows from financing activities:    
Proceeds from issuance of shares, net of issuance costs $ 11,913 $ 0