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v3.23.3

Summary of Significant Accounting Policies (Details) $ / shares in Units, shares in Thousands, $ in Thousands |  |  |  |  |  |  |  |  | 1 Months Ended | 9 Months Ended |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Aug. 01, 2023 USD ($) | Jun. 26, 2023 USD ($) $ / shares shares | May 01, 2023 | Apr. 04, 2023 USD ($) | Apr. 03, 2023 USD ($) $ / shares shares | Mar. 29, 2023 USD ($) | Feb. 05, 2020 | Feb. 16, 2018 | Oct. 31, 2023 USD ($) shares | Sep. 30, 2023 USD ($) $ / shares shares | Sep. 30, 2022 USD ($) | Mar. 31, 2023 USD ($) | Dec. 31, 2022 USD ($) $ / shares | Aug. 31, 2022 USD ($) | Feb. 14, 2020 USD ($)
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Term of orphan drug exclusivity |  |  | 7 years |  |  |  |  |  |  |  |  |  |  |  |
Maximum proceeds from royalty financing |  |  |  |  |  | $ 75,000 |  |  |  |  |  |  |  |  |
Proceeds from royalty purchase agreement |  |  |  |  |  |  |  |  |  | $ 30,000 | $ 0 |  |  |  |
Quarterly net revenue target for royalty financing |  |  |  |  |  | $ 25,000 |  |  |  |  |  |  |  |  |
Cash settlement of notes |  |  |  |  |  |  |  |  |  | $ 17,500 | $ 0 |  |  |  |
Number of ADSs issued upon settlement/ conversion (in shares) | shares |  | 12,347 |  |  |  |  |  |  |  |  |  |  |  |  |
Ordinary shares, nominal value (in dollars per share) | $ / shares |  | $ 0.01 |  |  | $ 0.01 |  |  |  |  | $ 0.01 |  |  | $ 0.01 |  |
Aggregate net proceeds from stock offering |  |  |  |  | $ 134,151 |  |  |  |  |  |  |  |  |  |
ADSs, conversion ratio |  | 0.1161846 |  |  |  |  |  | 92.6956 |  |  |  |  |  |  |
Aggregate amount of conversion |  | $ 1,470 |  |  |  |  |  |  |  |  |  |  |  |  |
2020 Shelf Registration Statement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Sales agent commission, as a percent of aggregate gross sales proceeds |  |  |  |  |  |  | 3.00% |  |  |  |  |  |  |  |
Maximum aggregate offering price of ADSs under shelf registration |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 50,000
2022 Shelf Registration Statement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maximum aggregate offering price of ADSs under shelf registration |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 100,000 |
At-The-Market Offering Program |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate net proceeds from stock offering |  |  |  |  |  |  |  |  |  | $ 11,913 |  |  |  |  |
Remaining authorized aggregate offering price under shelf registration |  |  |  |  |  |  |  |  |  | $ 96,064 |  |  |  |  |
American Depositary Shares | At-The-Market Offering Program |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares sold in offering (in shares) | shares |  |  |  |  |  |  |  |  |  | 1,564 |  |  |  |  |
American Depositary Shares | Subsequent Event |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of ADSs issued upon settlement/ conversion (in shares) | shares |  |  |  |  |  |  |  |  | 408 |  |  |  |  |  |
Ordinary shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares sold in offering (in shares) | shares |  |  |  |  | 12,205 |  |  |  |  |  |  |  |  |  |
Series B Non-Voting Convertible Preferred Shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares sold in offering (in shares) | shares |  |  |  |  | 4,706 |  |  |  |  |  |  |  |  |  |
4.50% Exchangeable Senior Notes Due October 2023 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Interest rate |  |  |  |  |  |  |  |  |  |  |  | 4.50% |  |  |
April 2027 Notes |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Interest rate |  |  |  | 6.00% |  |  |  |  |  |  |  |  |  |  |
Royalty Financing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from royalty purchase agreement | $ 30,000 |  |  |  |  |  |  |  |  | $ 30,000 |  |  |  |  |
Senior Notes | 4.50% Exchangeable Senior Notes Due October 2023 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Long-term debt |  |  |  |  |  |  |  |  |  | $ 21,187 |  | $ 117,375 | $ 117,375 |  |
Interest rate |  |  |  |  |  |  |  |  |  | 4.50% |  |  |  |  |
Debt exchanged |  |  |  | $ 96,188 |  |  |  |  |  |  |  |  |  |  |
Senior Notes | 4.50% Exchangeable Senior Notes Due October 2023 | Subsequent Event |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash settlement of notes |  |  |  |  |  |  |  |  | $ 21,641 |  |  |  |  |  |
Senior Notes | April 2027 Notes |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Long-term debt |  |  |  | 106,268 |  |  |  |  |  |  |  |  |  |  |
Debt exchanged |  | $ 106,268 |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate amount of conversion |  |  |  | $ 106,268 |  |  |  |  |  |  |  |  |  |  |

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