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Summary of Significant Accounting Policies (Details)
$ / shares in Units, shares in Thousands, $ in Thousands
 1 Months Ended 9 Months Ended
Aug. 01, 2023
USD ($)
Jun. 26, 2023
USD ($)
$ / shares
shares
May 01, 2023
Apr. 04, 2023
USD ($)
Apr. 03, 2023
USD ($)
$ / shares
shares
Mar. 29, 2023
USD ($)
Feb. 05, 2020
Feb. 16, 2018
Oct. 31, 2023
USD ($)
shares
Sep. 30, 2023
USD ($)
$ / shares
shares
Sep. 30, 2022
USD ($)
Mar. 31, 2023
USD ($)
Dec. 31, 2022
USD ($)
$ / shares
Aug. 31, 2022
USD ($)
Feb. 14, 2020
USD ($)
Class of Stock [Line Items]                              
Term of orphan drug exclusivity     7 years                        
Maximum proceeds from royalty financing           $ 75,000                  
Proceeds from royalty purchase agreement                   $ 30,000 $ 0        
Quarterly net revenue target for royalty financing           $ 25,000                  
Cash settlement of notes                   $ 17,500 $ 0        
Number of ADSs issued upon settlement/ conversion (in shares) | shares   12,347                          
Ordinary shares, nominal value (in dollars per share) | $ / shares   $ 0.01     $ 0.01         $ 0.01     $ 0.01    
Aggregate net proceeds from stock offering         $ 134,151                    
ADSs, conversion ratio   0.1161846           92.6956              
Aggregate amount of conversion   $ 1,470                          
2020 Shelf Registration Statement                              
Class of Stock [Line Items]                              
Sales agent commission, as a percent of aggregate gross sales proceeds             3.00%                
Maximum aggregate offering price of ADSs under shelf registration                             $ 50,000
2022 Shelf Registration Statement                              
Class of Stock [Line Items]                              
Maximum aggregate offering price of ADSs under shelf registration                           $ 100,000  
At-The-Market Offering Program                              
Class of Stock [Line Items]                              
Aggregate net proceeds from stock offering                   $ 11,913          
Remaining authorized aggregate offering price under shelf registration                   $ 96,064          
American Depositary Shares | At-The-Market Offering Program                              
Class of Stock [Line Items]                              
Shares sold in offering (in shares) | shares                   1,564          
American Depositary Shares | Subsequent Event                              
Class of Stock [Line Items]                              
Number of ADSs issued upon settlement/ conversion (in shares) | shares                 408            
Ordinary shares                              
Class of Stock [Line Items]                              
Shares sold in offering (in shares) | shares         12,205                    
Series B Non-Voting Convertible Preferred Shares                              
Class of Stock [Line Items]                              
Shares sold in offering (in shares) | shares         4,706                    
4.50% Exchangeable Senior Notes Due October 2023                              
Class of Stock [Line Items]                              
Interest rate                       4.50%      
April 2027 Notes                              
Class of Stock [Line Items]                              
Interest rate       6.00%                      
Royalty Financing                              
Class of Stock [Line Items]                              
Proceeds from royalty purchase agreement $ 30,000                 $ 30,000          
Senior Notes | 4.50% Exchangeable Senior Notes Due October 2023                              
Class of Stock [Line Items]                              
Long-term debt                   $ 21,187   $ 117,375 $ 117,375    
Interest rate                   4.50%          
Debt exchanged       $ 96,188                      
Senior Notes | 4.50% Exchangeable Senior Notes Due October 2023 | Subsequent Event                              
Class of Stock [Line Items]                              
Cash settlement of notes                 $ 21,641            
Senior Notes | April 2027 Notes                              
Class of Stock [Line Items]                              
Long-term debt       106,268                      
Debt exchanged   $ 106,268                          
Aggregate amount of conversion       $ 106,268