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CONDENSED CONSOLIDATED STATEMENTS OF SHAREHOLDERS’ EQUITY (DEFICIT) - USD ($)
shares in Thousands, $ in Thousands
Total
Ordinary shares
Preferred shares
Additional paid-in capital
Accumulated deficit
Accumulated other comprehensive loss
Beginning balance (in shares) at Dec. 31, 2021   58,620 488      
Beginning balance at Dec. 31, 2021 $ 78,244 $ 586 $ 5 $ 549,349 $ (447,756) $ (23,940)
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Net loss (26,424)       (26,424)  
Other comprehensive income (loss) (1,102)         (1,102)
Vesting of restricted shares (in shares)   119        
Vesting of restricted shares 0 $ 1   (1)    
Exercise of stock options (in shares)   275        
Exercise of stock options 1,906 $ 3   1,903    
Employee share purchase plan share issuance (in shares)   18        
Employee share purchase plan share issuance 103     103    
Share-based compensation expense 2,505     2,505    
Ending balance (in shares) at Mar. 31, 2022   59,032 488      
Ending balance at Mar. 31, 2022 55,232 $ 590 $ 5 553,859 (474,180) (25,042)
Beginning balance (in shares) at Dec. 31, 2021   58,620 488      
Beginning balance at Dec. 31, 2021 78,244 $ 586 $ 5 549,349 (447,756) (23,940)
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Net loss (110,014)          
Ending balance (in shares) at Sep. 30, 2022   60,885 488      
Ending balance at Sep. 30, 2022 (12,440) $ 608 $ 5 572,626 (557,770) (27,909)
Beginning balance (in shares) at Mar. 31, 2022   59,032 488      
Beginning balance at Mar. 31, 2022 55,232 $ 590 $ 5 553,859 (474,180) (25,042)
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Net loss (63,444)       (63,444)  
Other comprehensive income (loss) (1,286)         (1,286)
Vesting of restricted shares (in shares)   6        
Change in fair value of October 2023 Notes conversion feature 5,508     5,508    
Share-based compensation expense 658     658    
Ending balance (in shares) at Jun. 30, 2022   59,038 488      
Ending balance at Jun. 30, 2022 (3,332) $ 590 $ 5 560,025 (537,624) (26,328)
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Net loss (20,146)       (20,146)  
Other comprehensive income (loss) (1,581)         (1,581)
Issuance of common stock, net of issuance costs (in shares)   1,768        
Issuance of common stock, net of issuance costs 10,532 $ 17   10,515    
Issuance costs (19)     (19)    
Vesting of restricted shares (in shares)   8        
Exercise of stock options (in shares)   14        
Exercise of stock options 64     64    
Employee share purchase plan share issuance (in shares)   57        
Employee share purchase plan share issuance 119 $ 1   118    
Share-based compensation expense 1,923     1,923    
Ending balance (in shares) at Sep. 30, 2022   60,885 488      
Ending balance at Sep. 30, 2022 (12,440) $ 608 $ 5 572,626 (557,770) (27,909)
Beginning balance (in shares) at Dec. 31, 2022   62,878 488      
Beginning balance at Dec. 31, 2022 (21,145) $ 628 $ 5 589,783 (585,220) (26,341)
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Net loss (30,784)       (30,784)  
Other comprehensive income (loss) 315         315
Issuance of common stock, net of issuance costs (in shares)   1,564        
Issuance of common stock, net of issuance costs 11,913 $ 16   11,897    
Issuance costs (16)     (16)    
Vesting of restricted shares (in shares)   22        
Employee share purchase plan share issuance (in shares)   14        
Employee share purchase plan share issuance 29     29    
Share-based compensation expense 1,522     1,522    
Ending balance (in shares) at Mar. 31, 2023   64,478 488      
Ending balance at Mar. 31, 2023 (38,166) $ 644 $ 5 603,215 (616,004) (26,026)
Beginning balance (in shares) at Dec. 31, 2022   62,878 488      
Beginning balance at Dec. 31, 2022 (21,145) $ 628 $ 5 589,783 (585,220) (26,341)
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Net loss (131,490)          
Ending balance (in shares) at Sep. 30, 2023   89,398 5,194      
Ending balance at Sep. 30, 2023 110,149 $ 893 $ 52 851,865 (716,710) (25,951)
Beginning balance (in shares) at Mar. 31, 2023   64,478 488      
Beginning balance at Mar. 31, 2023 (38,166) $ 644 $ 5 603,215 (616,004) (26,026)
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Net loss (64,432)       (64,432)  
Other comprehensive income (loss) 83         83
Issuance of common stock, net of issuance costs (in shares)   12,205 4,706      
Issuance of common stock, net of issuance costs 134,151 $ 122 $ 47 133,982    
Mandatory Exchange of April 2027 Notes, net of issuance costs (in shares)   12,347        
Mandatory Exchange of April 2027 Notes, net of issuance costs 102,162 $ 123   102,039    
Exercise of stock options (in shares)   291        
Exercise of stock options 1,750 $ 4   1,746    
Share-based compensation expense 7,644     7,644    
Ending balance (in shares) at Jun. 30, 2023   89,321 5,194      
Ending balance at Jun. 30, 2023 143,192 $ 893 $ 52 848,626 (680,436) (25,943)
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Net loss (36,274)       (36,274)  
Other comprehensive income (loss) (8)         (8)
Issuance costs (350)     (350)    
Exercise of stock options (in shares)   44        
Exercise of stock options 261 $ 0   261    
Employee share purchase plan share issuance (in shares)   33        
Employee share purchase plan share issuance 201     201    
Share-based compensation expense 3,127     3,127    
Ending balance (in shares) at Sep. 30, 2023   89,398 5,194      
Ending balance at Sep. 30, 2023 $ 110,149 $ 893 $ 52 $ 851,865 $ (716,710) $ (25,951)