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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2023
Sep. 30, 2022
Cash flows from operating activities:    
Net loss $ (131,490) $ (110,014)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 1,784 907
Amortization of debt discount and debt issuance costs 2,796 4,147
Changes in deferred taxes 0 25,916
Share-based compensation expense 12,293 5,086
Loss on extinguishment of debt 13,129 0
Other adjustments (349) 1,506
Net changes in assets and liabilities    
Accounts receivable (6,239) 0
Inventories (5,286) 0
Prepaid expenses and other current assets (4,277) 27,948
Research and development tax credit receivable 1,918 27
Accounts payable & other current liabilities 3,837 (11,629)
Accrued expenses 10,621 4,277
Other assets and liabilities 781 (3,109)
Net cash used in operating activities (100,482) (54,938)
Cash flows from investing activities:    
Purchases of property and equipment 0 (716)
Proceeds from sales of marketable securities 125,498 59,873
Purchases of marketable securities (203,519) (2,334)
Net cash (used in) provided by investing activities (78,021) 56,823
Cash flows from financing activities:    
Payments for February 2023 Notes (17,500) 0
Payments for debt issuance costs (4,357) (4,803)
Proceeds from royalty purchase agreement 30,000 0
Proceeds from stock option exercises and employee share purchase plan 2,241 2,192
Net cash provided by financing activities 156,446 7,921
Effect of foreign currency exchange rate changes on cash and cash equivalents (113) 201
Net change in cash and cash equivalents (22,170) 10,007
Cash and cash equivalents at January 1, 73,981 50,708
Cash and cash equivalents at September 30, 51,811 60,715
Supplemental disclosures of cash flow information:    
Interest paid 4,520 9,660
Income taxes refund 0 (32,323)
Public Offering    
Cash flows from financing activities:    
Proceeds from issuance of shares, net of issuance costs 134,149 0
At-The-Market Offering Program    
Cash flows from financing activities:    
Proceeds from issuance of shares, net of issuance costs $ 11,913 $ 10,532