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Income Taxes - Additional Information (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Income Taxes [Line Items] |  |  |
Income tax (benefit) provision | $ (501) | $ 26,025 | $ (15,816)
Decrease in income tax provision | 26,526 |  |
Unrecognized tax benefits | 3,035 | 3,143 | 2,483
Income tax penalties and interest expense | 268 | 258 | 239
Income tax penalties and interest accrued | 2,372 | 2,103 | $ 1,777
Unremitted earnings | 3,854 |  |
Research tax credit receivable | 1,654 | 3,480 |
Orphan Drug tax credit |  |  |
Income Taxes [Line Items] |  |  |
Tax credit carryforwards | 3,059 |  |
Research and Development tax credits |  |  |
Income Taxes [Line Items] |  |  |
Tax credit carryforwards | 1,005 |  |
Ireland |  |  |
Income Taxes [Line Items] |  |  |
Net operating loss carryforwards | 111,647 |  |
Operating loss carryforwards, valuation allowance (decrease) | 25,087 |  |
Gross research tax credit | 817 | 568 |
U.S. |  |  |
Income Taxes [Line Items] |  |  |
Net operating loss carryforwards | 212,426 |  |
U.S. | 163(j) Credits |  |  |
Income Taxes [Line Items] |  |  |
Tax credit carryforwards | 5,469 |  |
France |  |  |
Income Taxes [Line Items] |  |  |
Gross research tax credit | 837 | $ 2,912 |
FSC |  |  |
Income Taxes [Line Items] |  |  |
Net operating loss carryforwards | 10,365 |  |
U.S. Holdings |  |  |
Income Taxes [Line Items] |  |  |
Net operating loss carryforwards | 195,595 |  |
U.S. Holdings | State |  |  |
Income Taxes [Line Items] |  |  |
Net operating loss carryforwards | $ 6,466 |  |

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