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Consolidated Statements of Shareholders' Equity (Deficit) - USD ($) shares in Thousands, $ in Thousands | Total | April 2027 Notes | October 2023 Notes | At-the-market offering program | Public offering | Cumulative Effect, Period of Adoption, Adjustment | Ordinary shares | Ordinary shares April 2027 Notes | Ordinary shares October 2023 Notes | Ordinary shares At-the-market offering program | Ordinary shares Public offering | Preferred shares | Preferred shares Public offering | Additional paid-in capital | Additional paid-in capital April 2027 Notes | Additional paid-in capital October 2023 Notes | Additional paid-in capital At-the-market offering program | Additional paid-in capital Public offering | Additional paid-in capital Cumulative Effect, Period of Adoption, Adjustment | Accumulated deficit | Accumulated deficit Cumulative Effect, Period of Adoption, Adjustment | Accumulated other comprehensive loss
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Beginning balance (in shares) at Dec. 31, 2020 |  |  |  |  |  |  | 58,396 |  |  |  |  | 488 |  |  |  |  |  |  |  |  |  |
Beginning balance at Dec. 31, 2020 | $ 162,266 |  |  |  |  | $ (12,939) | $ 583 |  |  |  |  | $ 5 |  | $ 566,916 |  |  |  |  | $ (26,699) | $ (384,187) | $ 13,760 | $ (21,051)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (77,329) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (77,329) |  |
Other comprehensive income (loss) | (2,889) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (2,889)
Exercise of stock options (in shares) |  |  |  |  |  |  | 48 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise of stock options | 169 |  |  |  |  |  | $ 1 |  |  |  |  |  |  | 168 |  |  |  |  |  |  |  |
Vesting of restricted shares (in shares) |  |  |  |  |  |  | 159 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Vesting of restricted shares | 0 |  |  |  |  |  | $ 2 |  |  |  |  |  |  | (2) |  |  |  |  |  |  |  |
Employee share purchase plan share issuance (in shares) |  |  |  |  |  |  | 17 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Employee share purchase plan share issuance | 94 |  |  |  |  |  |  |  |  |  |  |  |  | 94 |  |  |  |  |  |  |  |
Share-based compensation expense | 8,872 |  |  |  |  |  |  |  |  |  |  |  |  | 8,872 |  |  |  |  |  |  |  |
Ending balance (in shares) at Dec. 31, 2021 |  |  |  |  |  |  | 58,620 |  |  |  |  | 488 |  |  |  |  |  |  |  |  |  |
Ending balance at Dec. 31, 2021 | 78,244 |  |  |  |  |  | $ 586 |  |  |  |  | $ 5 |  | 549,349 |  |  |  |  | $ (26,699) | (447,756) | $ 13,760 | (23,940)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (137,464) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (137,464) |  |
Other comprehensive income (loss) | (2,401) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (2,401)
Change in fair value of October 2023 Notes conversion feature | 5,508 |  |  |  |  |  |  |  |  |  |  |  |  | 5,508 |  |  |  |  |  |  |  |
Issuance of common stock, net of issuance costs (in shares) |  |  |  |  |  |  |  |  |  | 3,588 |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock, net of issuance costs |  |  |  | $ 25,318 |  |  |  |  |  | $ 36 |  |  |  |  |  |  | $ 25,282 |  |  |  |  |
Amortization of deferred issuance costs | (45) |  |  |  |  |  |  |  |  |  |  |  |  | (45) |  |  |  |  |  |  |  |
Exercise of stock options (in shares) |  |  |  |  |  |  | 451 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise of stock options | 2,460 |  |  |  |  |  | $ 4 |  |  |  |  |  |  | 2,456 |  |  |  |  |  |  |  |
Vesting of restricted shares (in shares) |  |  |  |  |  |  | 144 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Vesting of restricted shares | 0 |  |  |  |  |  | $ 1 |  |  |  |  |  |  | (1) |  |  |  |  |  |  |  |
Employee share purchase plan share issuance (in shares) |  |  |  |  |  |  | 75 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Employee share purchase plan share issuance | 222 |  |  |  |  |  | $ 1 |  |  |  |  |  |  | 221 |  |  |  |  |  |  |  |
Share-based compensation expense | 7,013 |  |  |  |  |  |  |  |  |  |  |  |  | 7,013 |  |  |  |  |  |  |  |
Ending balance (in shares) at Dec. 31, 2022 |  |  |  |  |  |  | 62,878 |  |  |  |  | 488 |  |  |  |  |  |  |  |  |  |
Ending balance at Dec. 31, 2022 | (21,145) |  |  |  |  |  | $ 628 |  |  |  |  | $ 5 |  | 589,783 |  |  |  |  |  | (585,220) |  | (26,341)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (160,276) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (160,276) |  |
Other comprehensive income (loss) | 3,174 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,174
Issuance of common stock, net of issuance costs (in shares) |  |  |  |  |  |  |  |  |  | 1,564 | 12,205 |  | 4,706 |  |  |  |  |  |  |  |  |
Issuance of common stock, net of issuance costs |  |  |  | $ 11,913 | $ 134,151 |  |  |  |  | $ 16 | $ 122 |  | $ 47 |  |  |  | $ 11,897 | $ 133,982 |  |  |  |
Amortization of deferred issuance costs | $ (16) |  |  |  |  |  |  |  |  |  |  |  |  | (16) |  |  |  |  |  |  |  |
Exchange/Settlement of Notes (in shares) |  |  |  |  |  |  |  | 12,347 | 408 |  |  |  |  |  |  |  |  |  |  |  |  |
Exchange/Settlement of Notes |  | $ 101,812 | $ 22 |  |  |  |  | $ 123 | $ 4 |  |  |  |  |  | $ 101,689 | $ 18 |  |  |  |  |  |
Exercise of stock options (in shares) | 342 |  |  |  |  |  | 343 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise of stock options | $ 2,062 |  |  |  |  |  | $ 4 |  |  |  |  |  |  | 2,058 |  |  |  |  |  |  |  |
Vesting of restricted shares (in shares) |  |  |  |  |  |  | 33 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Employee share purchase plan share issuance (in shares) |  |  |  |  |  |  | 47 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Employee share purchase plan share issuance | 231 |  |  |  |  |  | $ 1 |  |  |  |  |  |  | 230 |  |  |  |  |  |  |  |
Share-based compensation expense | 15,811 |  |  |  |  |  |  |  |  |  |  |  |  | 15,811 |  |  |  |  |  |  |  |
Ending balance (in shares) at Dec. 31, 2023 |  |  |  |  |  |  | 89,825 |  |  |  |  | 5,194 |  |  |  |  |  |  |  |  |  |
Ending balance at Dec. 31, 2023 | $ 87,739 |  |  |  |  |  | $ 898 |  |  |  |  | $ 52 |  | $ 855,452 |  |  |  |  |  | $ (745,496) |  | $ (23,167)

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