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Equity Instruments and Transactions (Details) - USD ($)
$ / shares in Units, $ in Thousands
 1 Months Ended 12 Months Ended
Apr. 03, 2023
Feb. 29, 2020
Dec. 31, 2023
Dec. 31, 2022
Jun. 26, 2023
Aug. 31, 2022
Class of Stock [Line Items]            
Ordinary shares, shares authorized (in shares)     500,000,000 500,000,000    
Ordinary shares, nominal value (in usd per share) $ 0.01   $ 0.01 $ 0.01 $ 0.01  
Ordinary shares, shares issued (in shares)     89,825,000 62,878,000    
Ordinary shares, shares outstanding (in shares)     89,825,000 62,878,000    
Preferred shares, shares authorized (in shares)     50,000,000 50,000,000    
Preferred shares, nominal value (in usd per share)   $ 0.01 $ 0.01 $ 0.01    
Preferred shares, shares issued (in shares)     5,194,000 488,000    
Preferred shares, shares outstanding (in shares)     5,194,000 488,000    
Net proceeds from shares issued $ 134,151          
Prepaid expenses and other current assets     $ 5,286 $ 2,096    
Restricted Shares            
Class of Stock [Line Items]            
Granted (in shares)     0 0    
Ordinary shares            
Class of Stock [Line Items]            
Shares issued (in shares) 12,205,000          
Series B Non-Voting Convertible Preferred Shares            
Class of Stock [Line Items]            
Shares issued (in shares) 4,706,000          
2020 Shelf Registration Statement            
Class of Stock [Line Items]            
Maximum aggregate offering price of securities under shelf registration   $ 250        
Maximum aggregate offering price of ADSs under shelf registration   $ 50        
Sales agent commission, as a percent of aggregate gross sales proceeds   3.00%        
At-the-market offering program            
Class of Stock [Line Items]            
Issuance of common stock, net of issuance costs     $ 11,913 $ 25,318    
Net proceeds from shares issued     11,913      
Remaining authorized aggregate offering price under registration     96,064      
At-the-market offering program | Ordinary shares            
Class of Stock [Line Items]            
Issuance of common stock, net of issuance costs     $ 16 $ 36    
At-the-market offering program | American Depositary Shares            
Class of Stock [Line Items]            
Shares issued (in shares)     1,564,000 3,588,000    
2022 Shelf Registration Statement            
Class of Stock [Line Items]            
Maximum aggregate offering price of securities under shelf registration           $ 500
Maximum aggregate offering price of ADSs under shelf registration           $ 100
Transaction costs     $ 192      
Prepaid expenses and other current assets     $ 135