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Summary of Significant Accounting Policies (Details) - USD ($) $ / shares in Units, $ in Thousands |  | 1 Months Ended | 3 Months Ended |  |
--- | --- | --- | --- | --- | ---
May 01, 2023 | Feb. 29, 2020 | Mar. 31, 2024 | Dec. 31, 2023 | Aug. 31, 2022
Class of Stock [Line Items] |  |  |  |  |
Term of orphan drug exclusivity | 7 years |  |  |  |
Ordinary shares, nominal value (in dollars per share) |  |  | $ 0.01 | $ 0.01 |
Preferred shares, shares issued (in shares) |  |  | 0 | 5,194,000 |
Preferred shares, shares outstanding (in shares) |  |  | 0 | 5,194,000 |
Preferred shares |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |
Shares converted (in shares) |  |  | (5,194,000) |  |
Ordinary shares |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |
Shares converted (in shares) |  |  | 5,194,000 |  |
2020 Shelf Registration Statement |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |
Sales agent commission, as a percent of aggregate gross sales proceeds |  | 3.00% |  |  |
Maximum aggregate offering price of ADSs under shelf registration |  | $ 50,000 |  |  |
2022 Shelf Registration Statement |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |
Maximum aggregate offering price of ADSs under shelf registration |  |  |  |  | $ 100,000
At-The-Market Offering Program |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |
Aggregate net proceeds from stock offering |  |  | $ 9,250 |  |
Remaining authorized aggregate offering price under shelf registration |  |  | $ 86,528 |  |
At-The-Market Offering Program | American Depositary Shares |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |
Shares sold in offering (in shares) |  |  | 640,000 |  |

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