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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2024
Jun. 30, 2023
Cash flows from operating activities:    
Net loss $ (41,164) $ (95,216)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 978 1,189
Amortization of debt discount and debt issuance costs 0 2,460
Share-based compensation expense 10,851 9,166
Loss on extinguishment of debt 0 13,129
Other adjustments (1,208) 42
Net changes in assets and liabilities    
Accounts receivable (21,274) (1,775)
Inventories (2,264) (1,439)
Prepaid expenses and other current assets (1,557) (4,400)
Research and development tax credit receivable 451 2,127
Accounts payable & other current liabilities (1,638) 2,470
Accrued expenses 9,484 10,246
Other assets and liabilities (549) (255)
Net cash used in operating activities (47,890) (62,256)
Cash flows from investing activities:    
Proceeds from sales of marketable securities 207,835 25,618
Purchases of marketable securities (175,898) (113,460)
Net cash provided by (used in) investing activities 31,937 (87,842)
Cash flows from financing activities:    
Payments for February 2023 Notes 0 (17,500)
Payments for debt issuance costs 0 (4,357)
Proceeds from stock option exercises and employee share purchase plan 4,663 1,779
Net cash provided by financing activities 13,913 125,986
Effect of foreign currency exchange rate changes on cash and cash equivalents (280) 116
Net change in cash and cash equivalents (2,320) (23,996)
Cash and cash equivalents at January 1, 31,167 73,981
Cash and cash equivalents at June 30, 28,847 49,985
Supplemental disclosures of cash flow information:    
Interest paid 1,748 4,520
Public Offering    
Cash flows from financing activities:    
Proceeds from issuance of shares, net of issuance costs 0 134,151
At-The-Market Offering Program    
Cash flows from financing activities:    
Proceeds from issuance of shares, net of issuance costs $ 9,250 $ 11,913