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CONDENSED CONSOLIDATED STATEMENTS OF SHAREHOLDERS’ EQUITY - USD ($) shares in Thousands, $ in Thousands | Total | Ordinary shares | Preferred shares | Additional paid-in capital | Accumulated deficit | Accumulated other comprehensive loss
--- | --- | --- | --- | --- | --- | ---
Beginning balance (in shares) at Dec. 31, 2022 |  | 62,878 | 488 |  |  |
Beginning balance at Dec. 31, 2022 | $ (21,145) | $ 628 | $ 5 | $ 589,783 | $ (585,220) | $ (26,341)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Net loss | (30,784) |  |  |  | (30,784) |
Other comprehensive (loss) income | 315 |  |  |  |  | 315
Issuance of common stock, net of issuance costs (in shares) |  | 1,564 |  |  |  |
Issuance of common stock, net of issuance costs | 11,913 | $ 16 |  | 11,897 |  |
Amortization of deferred issuance costs | (16) |  |  | (16) |  |
Vesting of restricted shares (in shares) |  | 22 |  |  |  |
Employee share purchase plan share issuance (in shares) |  | 14 |  |  |  |
Employee share purchase plan share issuance | 29 |  |  | 29 |  |
Share-based compensation expense | 1,522 |  |  | 1,522 |  |
Ending balance (in shares) at Mar. 31, 2023 |  | 64,478 | 488 |  |  |
Ending balance at Mar. 31, 2023 | (38,166) | $ 644 | $ 5 | 603,215 | (616,004) | (26,026)
Beginning balance (in shares) at Dec. 31, 2022 |  | 62,878 | 488 |  |  |
Beginning balance at Dec. 31, 2022 | (21,145) | $ 628 | $ 5 | 589,783 | (585,220) | (26,341)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Net loss | (131,490) |  |  |  |  |
Other comprehensive (loss) income | 391 |  |  |  |  |
Ending balance (in shares) at Sep. 30, 2023 |  | 89,398 | 5,194 |  |  |
Ending balance at Sep. 30, 2023 | 110,149 | $ 893 | $ 52 | 851,865 | (716,710) | (25,951)
Beginning balance (in shares) at Mar. 31, 2023 |  | 64,478 | 488 |  |  |
Beginning balance at Mar. 31, 2023 | (38,166) | $ 644 | $ 5 | 603,215 | (616,004) | (26,026)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Net loss | (64,432) |  |  |  | (64,432) |
Other comprehensive (loss) income | 83 |  |  |  |  | 83
Issuance of common stock, net of issuance costs (in shares) |  | 12,205 | 4,706 |  |  |
Issuance of common stock, net of issuance costs | 134,151 | $ 122 | $ 47 | 133,982 |  |
Conversion of preferred stock into ordinary shares/ Mandatory exchange of notes, net of issuance costs (in shares) |  | 12,347 |  |  |  |
Conversion of preferred stock into ordinary shares/ Mandatory exchange of notes, net of issuance costs | 102,162 | $ 123 |  | 102,039 |  |
Exercise of stock options (in shares) |  | 291 |  |  |  |
Exercise of stock options | 1,750 | $ 4 |  | 1,746 |  |
Share-based compensation expense | 7,644 |  |  | 7,644 |  |
Ending balance (in shares) at Jun. 30, 2023 |  | 89,321 | 5,194 |  |  |
Ending balance at Jun. 30, 2023 | 143,192 | $ 893 | $ 52 | 848,626 | (680,436) | (25,943)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Net loss | (36,274) |  |  |  | (36,274) |
Other comprehensive (loss) income | (8) |  |  |  |  | (8)
Conversion of preferred stock into ordinary shares/ Mandatory exchange of notes, net of issuance costs | (350) |  |  |  |  |
Exercise of stock options (in shares) |  | 44 |  |  |  |
Exercise of stock options | 261 |  |  | 261 |  |
Employee share purchase plan share issuance (in shares) |  | 33 |  |  |  |
Employee share purchase plan share issuance | 201 |  |  | 201 |  |
Share-based compensation expense | 3,127 |  |  | 3,127 |  |
Ending balance (in shares) at Sep. 30, 2023 |  | 89,398 | 5,194 |  |  |
Ending balance at Sep. 30, 2023 | 110,149 | $ 893 | $ 52 | 851,865 | (716,710) | (25,951)
Beginning balance (in shares) at Dec. 31, 2023 |  | 89,825 | 5,194 |  |  |
Beginning balance at Dec. 31, 2023 | 87,739 | $ 898 | $ 52 | 855,452 | (745,496) | (23,167)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Net loss | (27,342) |  |  |  | (27,342) |
Other comprehensive (loss) income | (589) |  |  |  |  | (589)
Issuance of common stock, net of issuance costs (in shares) |  | 640 |  |  |  |
Issuance of common stock, net of issuance costs | 9,250 | $ 6 |  | 9,244 |  |
Amortization of deferred issuance costs | (3) |  |  | (3) |  |
Conversion of preferred stock into ordinary shares/ Mandatory exchange of notes, net of issuance costs (in shares) |  | 5,194 | 5,194 |  |  |
Conversion of preferred stock into ordinary shares/ Mandatory exchange of notes, net of issuance costs | 0 | $ 52 | $ (52) |  |  |
Exercise of stock options (in shares) |  | 390 |  |  |  |
Exercise of stock options | 3,356 | $ 3 |  | 3,353 |  |
Employee share purchase plan share issuance (in shares) |  | 48 |  |  |  |
Employee share purchase plan share issuance | 584 | $ 1 |  | 583 |  |
Share-based compensation expense | 5,389 |  |  | 5,389 |  |
Ending balance (in shares) at Mar. 31, 2024 |  | 96,097 | 0 |  |  |
Ending balance at Mar. 31, 2024 | 78,384 | $ 960 | $ 0 | 874,018 | (772,838) | (23,756)
Beginning balance (in shares) at Dec. 31, 2023 |  | 89,825 | 5,194 |  |  |
Beginning balance at Dec. 31, 2023 | 87,739 | $ 898 | $ 52 | 855,452 | (745,496) | (23,167)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Net loss | (43,789) |  |  |  |  |
Other comprehensive (loss) income | (635) |  |  |  |  |
Ending balance (in shares) at Sep. 30, 2024 |  | 96,338 | 0 |  |  |
Ending balance at Sep. 30, 2024 | 74,663 | $ 963 | $ 0 | 886,787 | (789,285) | (23,802)
Beginning balance (in shares) at Mar. 31, 2024 |  | 96,097 | 0 |  |  |
Beginning balance at Mar. 31, 2024 | 78,384 | $ 960 | $ 0 | 874,018 | (772,838) | (23,756)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Net loss | (13,822) |  |  |  | (13,822) |
Other comprehensive (loss) income | (459) |  |  |  |  | (459)
Exercise of stock options (in shares) |  | 107 |  |  |  |
Exercise of stock options | 723 | $ 1 |  | 722 |  |
Share-based compensation expense | 5,462 |  |  | 5,462 |  |
Ending balance (in shares) at Jun. 30, 2024 |  | 96,204 | 0 |  |  |
Ending balance at Jun. 30, 2024 | 70,288 | $ 961 | $ 0 | 880,202 | (786,660) | (24,215)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Net loss | (2,625) |  |  |  | (2,625) |
Other comprehensive (loss) income | 413 |  |  |  |  | 413
Exercise of stock options (in shares) |  | 69 |  |  |  |
Exercise of stock options | 400 | $ 1 |  | 399 |  |
Employee share purchase plan share issuance (in shares) |  | 65 |  |  |  |
Employee share purchase plan share issuance | 777 | $ 1 |  | 776 |  |
Share-based compensation expense | 5,410 |  |  | 5,410 |  |
Ending balance (in shares) at Sep. 30, 2024 |  | 96,338 | 0 |  |  |
Ending balance at Sep. 30, 2024 | $ 74,663 | $ 963 | $ 0 | $ 886,787 | $ (789,285) | $ (23,802)

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