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Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Cash flows from operating activities: |  |  |
Net loss | $ (48,832) | $ (160,276) | $ (137,464)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 2,681 | 1,766 | 1,493
Amortization of debt discount and debt issuance costs | 0 | 2,796 | 6,052
Changes in deferred taxes | 0 | 0 | 26,025
Share-based compensation expense | 20,387 | 15,811 | 7,013
Loss on extinguishment of debt | 0 | 13,129 | 0
Other adjustments | (828) | 1,262 | 2,042
Net changes in assets and liabilities |  |  |
Accounts receivable | (21,994) | (12,103) | 0
Inventories | (9,219) | (9,532) | 0
Prepaid expenses and other current assets | 416 | (2,155) | 30,950
Accounts payable & other current liabilities | (4,093) | 1,545 | (3,108)
Accrued expenses | 16,424 | 16,892 | 227
Other assets and liabilities | (1,849) | 2,354 | (3,534)
Net cash used in operating activities | (46,907) | (128,511) | (70,304)
Cash flows from investing activities: |  |  |
Purchases of property and equipment | 0 | 0 | (716)
Proceeds from sales of marketable securities | 327,781 | 187,136 | 83,828
Purchases of marketable securities | (276,001) | (237,229) | (3,414)
Net cash provided by (used in) investing activities | 51,780 | (50,093) | 79,698
Cash flows from financing activities: |  |  |
Proceeds from stock option exercises and employee share purchase plan | 6,720 | 2,293 | 2,682
Payments for debt issuance costs | 0 | (4,357) | (4,804)
Proceeds from royalty purchase agreement | 0 | 30,000 | 0
Net cash provided by financing activities | 15,970 | 135,335 | 14,543
Effect of foreign currency exchange rate changes on cash and cash equivalents | (639) | 455 | (664)
Net change in cash and cash equivalents | 20,204 | (42,814) | 23,273
Cash and cash equivalents at January 1 | 31,167 | 73,981 | 50,708
Cash and cash equivalents at December 31 | 51,371 | 31,167 | 73,981
Supplemental disclosures of cash flow information: |  |  |
Interest paid | 7,181 | 5,250 | 9,660
Income taxes refunded, net | 0 | 0 | (29,058)
February 2023 Notes |  |  |
Cash flows from financing activities: |  |  |
Payments for Notes | 0 | (17,500) | (8,653)
October 2023 Notes |  |  |
Cash flows from financing activities: |  |  |
Payments for Notes | 0 | (21,165) | 0
Public offering |  |  |
Cash flows from financing activities: |  |  |
Proceeds from issuance of shares, net of issue costs | 0 | 134,151 | 0
At-the-market offering program |  |  |
Cash flows from financing activities: |  |  |
Proceeds from issuance of shares, net of issue costs | $ 9,250 | $ 11,913 | $ 25,318

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