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Consolidated Statements of Shareholders' Equity - USD ($) shares in Thousands, $ in Thousands | Total | April 2027 Notes | October 2023 Notes | At-the-market offering program | Public offering | Ordinary shares | Ordinary shares April 2027 Notes | Ordinary shares October 2023 Notes | Ordinary shares At-the-market offering program | Ordinary shares Public offering | Preferred shares | Preferred shares Public offering | Additional paid-in capital | Additional paid-in capital April 2027 Notes | Additional paid-in capital October 2023 Notes | Additional paid-in capital At-the-market offering program | Additional paid-in capital Public offering | Accumulated deficit | Accumulated other comprehensive loss
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Beginning balance (in shares) at Dec. 31, 2021 |  |  |  |  |  | 58,620 |  |  |  |  | 488 |  |  |  |  |  |  |  |
Beginning balance at Dec. 31, 2021 | $ 78,244 |  |  |  |  | $ 586 |  |  |  |  | $ 5 |  | $ 549,349 |  |  |  |  | $ (447,756) | $ (23,940)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (137,464) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (137,464) |
Net other comprehensive (loss) income | (2,401) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (2,401)
Change in fair value of October 2023 Notes conversion feature | 5,508 |  |  |  |  |  |  |  |  |  |  |  | 5,508 |  |  |  |  |  |
Issuance of common stock, net of issuance costs (in shares) |  |  |  |  |  |  |  |  | 3,588 |  |  |  |  |  |  |  |  |  |
Issuance of common stock, net of issuance costs | 25,318 |  |  |  |  |  |  |  | $ 36 |  |  |  | 25,282 |  |  |  |  |  |
Amortization of deferred issuance costs | (45) |  |  |  |  |  |  |  |  |  |  |  | (45) |  |  |  |  |  |
Exercise of stock options (in shares) |  |  |  |  |  | 451 |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise of stock options | 2,460 |  |  |  |  | $ 4 |  |  |  |  |  |  | 2,456 |  |  |  |  |  |
Vesting of restricted shares (in shares) |  |  |  |  |  | 144 |  |  |  |  |  |  |  |  |  |  |  |  |
Vesting of restricted shares | 0 |  |  |  |  | $ 1 |  |  |  |  |  |  | (1) |  |  |  |  |  |
Employee share purchase plan share issuance (in shares) |  |  |  |  |  | 75 |  |  |  |  |  |  |  |  |  |  |  |  |
Employee share purchase plan share issuance | 222 |  |  |  |  | $ 1 |  |  |  |  |  |  | 221 |  |  |  |  |  |
Share-based compensation expense | 7,013 |  |  |  |  |  |  |  |  |  |  |  | 7,013 |  |  |  |  |  |
Ending balance (in shares) at Dec. 31, 2022 |  |  |  |  |  | 62,878 |  |  |  |  | 488 |  |  |  |  |  |  |  |
Ending balance at Dec. 31, 2022 | (21,145) |  |  |  |  | $ 628 |  |  |  |  | $ 5 |  | 589,783 |  |  |  |  | (585,220) | (26,341)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (160,276) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (160,276) |
Net other comprehensive (loss) income | 3,174 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,174
Issuance of common stock, net of issuance costs (in shares) |  |  |  |  |  |  |  |  | 1,564 | 12,205 |  | 4,706 |  |  |  |  |  |  |
Issuance of common stock, net of issuance costs |  |  |  | $ 11,913 | $ 134,151 |  |  |  | $ 16 | $ 122 |  | $ 47 |  |  |  | $ 11,897 | $ 133,982 |  |
Amortization of deferred issuance costs | (16) |  |  |  |  |  |  |  |  |  |  |  | (16) |  |  |  |  |  |
Exchange/Settlement of Notes (in shares) |  |  |  |  |  |  | 12,347 | 408 |  |  |  |  |  |  |  |  |  |  |
Exchange/Settlement of Notes |  | $ 101,812 | $ 22 |  |  |  | $ 123 | $ 4 |  |  |  |  |  | $ 101,689 | $ 18 |  |  |  |
Exercise of stock options (in shares) |  |  |  |  |  | 343 |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise of stock options | 2,062 |  |  |  |  | $ 4 |  |  |  |  |  |  | 2,058 |  |  |  |  |  |
Vesting of restricted shares (in shares) |  |  |  |  |  | 33 |  |  |  |  |  |  |  |  |  |  |  |  |
Employee share purchase plan share issuance (in shares) |  |  |  |  |  | 47 |  |  |  |  |  |  |  |  |  |  |  |  |
Employee share purchase plan share issuance | 231 |  |  |  |  | $ 1 |  |  |  |  |  |  | 230 |  |  |  |  |  |
Share-based compensation expense | 15,811 |  |  |  |  |  |  |  |  |  |  |  | 15,811 |  |  |  |  |  |
Ending balance (in shares) at Dec. 31, 2023 |  |  |  |  |  | 89,825 |  |  |  |  | 5,194 |  |  |  |  |  |  |  |
Ending balance at Dec. 31, 2023 | 87,739 |  |  |  |  | $ 898 |  |  |  |  | $ 52 |  | 855,452 |  |  |  |  | (745,496) | (23,167)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (48,832) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (48,832) |
Net other comprehensive (loss) income | (1,413) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (1,413)
Issuance of common stock, net of issuance costs (in shares) |  |  |  |  |  |  |  |  | 640 |  |  |  |  |  |  |  |  |  |
Issuance of common stock, net of issuance costs | 9,250 |  |  |  |  |  |  |  | $ 6 |  |  |  |  |  |  | $ 9,244 |  |  |
Amortization of deferred issuance costs | (3) |  |  |  |  |  |  |  |  |  |  |  | (3) |  |  |  |  |  |
Exchange/Settlement of Notes (in shares) |  |  |  |  |  | 5,194 |  |  |  |  | (5,194) |  |  |  |  |  |  |  |
Exchange/Settlement of Notes | $ 0 |  |  |  |  | $ 52 |  |  |  |  | $ (52) |  |  |  |  |  |  |  |
Exercise of stock options (in shares) | 734 |  |  |  |  | 735 |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise of stock options | $ 5,359 |  |  |  |  | $ 8 |  |  |  |  |  |  | 5,351 |  |  |  |  |  |
Vesting of restricted shares (in shares) |  |  |  |  |  | 11 |  |  |  |  |  |  |  |  |  |  |  |  |
Employee share purchase plan share issuance (in shares) |  |  |  |  |  | 113 |  |  |  |  |  |  |  |  |  |  |  |  |
Employee share purchase plan share issuance | 1,361 |  |  |  |  | $ 1 |  |  |  |  |  |  | 1,360 |  |  |  |  |  |
Share-based compensation expense | 20,387 |  |  |  |  |  |  |  |  |  |  |  | 20,387 |  |  |  |  |  |
Ending balance (in shares) at Dec. 31, 2024 |  |  |  |  |  | 96,518 |  |  |  |  | 0 |  |  |  |  |  |  |  |
Ending balance at Dec. 31, 2024 | $ 73,848 |  |  |  |  | $ 965 |  |  |  |  | $ 0 |  | $ 891,791 |  |  |  |  | $ (794,328) | $ (24,580)

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