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Income Taxes - Reconciliation of Tax Rate (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Effective Income Tax Rate Reconciliation, Amount [Abstract]
Income tax (benefit) provision - at statutory tax rate	$ (6,135)	$ (20,097)	$ (13,916)
Differences in international tax rates	(2,991)	(6,635)	(9,921)
Return to Provision	2,632	856	(101)
Change in valuation allowances	4,982	24,332	48,734
Nondeductible share-based compensation	1,444	798	1,424
Unrealized tax benefits	(218)	160	258
State and local taxes (net of federal)	778	(5,614)	(4,467)
Nondeductible interest expense	(848)	4,362	4,239
Orphan drug and R&D tax credit	(30)	899	0
Other	139	438	(225)
Income tax (benefit) provision	$ (247)	$ (501)	$ 26,025

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