<SEC-DOCUMENT>0001209191-20-054565.txt : 20201009
<SEC-HEADER>0001209191-20-054565.hdr.sgml : 20201009
<ACCEPTANCE-DATETIME>20201009190123
ACCESSION NUMBER:		0001209191-20-054565
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20201007
FILED AS OF DATE:		20201009
DATE AS OF CHANGE:		20201009

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			SHAW DAVID E
		CENTRAL INDEX KEY:			0001023870
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-39206
		FILM NUMBER:		201234226

	MAIL ADDRESS:	
		STREET 1:		120 WEST FORTY-FIFTH STREET
		STREET 2:		39TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10036

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Schrodinger Equity Holdings, LLC
		CENTRAL INDEX KEY:			0001801739
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-39206
		FILM NUMBER:		201234227

	BUSINESS ADDRESS:	
		STREET 1:		120 WEST 45TH STREET, 39TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10036
		BUSINESS PHONE:		(212) 403-8007

	MAIL ADDRESS:	
		STREET 1:		120 WEST 45TH STREET, 39TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10036

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Schrodinger, Inc.
		CENTRAL INDEX KEY:			0001490978
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				954284541
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		120 WEST 45TH STREET
		STREET 2:		17TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10036
		BUSINESS PHONE:		503-299-1150

	MAIL ADDRESS:	
		STREET 1:		120 WEST 45TH STREET
		STREET 2:		17TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10036
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<DESCRIPTION>FORM 4 SUBMISSION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2020-10-07</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001490978</issuerCik>
        <issuerName>Schrodinger, Inc.</issuerName>
        <issuerTradingSymbol>SDGR</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001023870</rptOwnerCik>
            <rptOwnerName>SHAW DAVID E</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>120 WEST 45TH STREET, 39TH FLOOR</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10036</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001801739</rptOwnerCik>
            <rptOwnerName>Schrodinger Equity Holdings, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>120 WEST 45TH STREET, 39TH FLOOR</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10036</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, par value $0.01 per share</value>
            </securityTitle>
            <transactionDate>
                <value>2020-10-07</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>52232</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>53.2941</value>
                    <footnoteId id="F2"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>32807</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>Held by D.E. Shaw &amp; Co., L.P.</value>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, par value $0.01 per share</value>
            </securityTitle>
            <transactionDate>
                <value>2020-10-07</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>11537</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>54.2244</value>
                    <footnoteId id="F4"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>21270</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>Held by D.E. Shaw &amp; Co., L.P.</value>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, par value $0.01 per share</value>
            </securityTitle>
            <transactionDate>
                <value>2020-10-07</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>21250</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>54.9643</value>
                    <footnoteId id="F5"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>20</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>Held by D.E. Shaw &amp; Co., L.P.</value>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, par value $0.01 per share</value>
            </securityTitle>
            <transactionDate>
                <value>2020-10-07</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>20</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>56.00</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>0</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>Held by D.E. Shaw &amp; Co., L.P.</value>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, par value $0.01 per share</value>
            </securityTitle>
            <transactionDate>
                <value>2020-10-07</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>131022</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>53.879</value>
                    <footnoteId id="F6"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>14759823</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>Held by Schrodinger Equity Holdings, LLC</value>
                    <footnoteId id="F7"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, par value $0.01 per share</value>
            </securityTitle>
            <transactionDate>
                <value>2020-10-08</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>82342</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>53.6468</value>
                    <footnoteId id="F8"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>14677481</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>Held by Schrodinger Equity Holdings, LLC</value>
                    <footnoteId id="F7"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, par value $0.01 per share</value>
            </securityTitle>
            <transactionDate>
                <value>2020-10-08</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>88919</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>54.617</value>
                    <footnoteId id="F9"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>14588562</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>Held by Schrodinger Equity Holdings, LLC</value>
                    <footnoteId id="F7"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, par value $0.01 per share</value>
            </securityTitle>
            <transactionDate>
                <value>2020-10-08</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>59837</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>55.2784</value>
                    <footnoteId id="F10"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>14528725</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>Held by Schrodinger Equity Holdings, LLC</value>
                    <footnoteId id="F7"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, par value $0.01 per share</value>
            </securityTitle>
            <transactionDate>
                <value>2020-10-09</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>100000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>54.8628</value>
                    <footnoteId id="F11"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>14428725</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>Held by Schrodinger Equity Holdings, LLC</value>
                    <footnoteId id="F7"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, par value $0.01 per share</value>
            </securityTitle>
            <transactionDate>
                <value>2020-10-09</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>210000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>55.9878</value>
                    <footnoteId id="F12"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>14218725</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>Held by Schrodinger Equity Holdings, LLC</value>
                    <footnoteId id="F7"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, par value $0.01 per share</value>
            </securityTitle>
            <transactionDate>
                <value>2020-10-09</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>162634</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>56.6855</value>
                    <footnoteId id="F13"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>14056091</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>Held by Schrodinger Equity Holdings, LLC</value>
                    <footnoteId id="F7"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock, par value $0.01 per share</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>4264</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>Held by D. E. Shaw Technology Development, LLC</value>
                    <footnoteId id="F14"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.</footnote>
        <footnote id="F2">This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $52.88 to $53.865, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.</footnote>
        <footnote id="F3">David E. Shaw is President and sole shareholder of D. E. Shaw &amp; Co., Inc., which is the general partner of D. E. Shaw &amp; Co., L.P. David E. Shaw disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, if any.</footnote>
        <footnote id="F4">This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $53.89 to $54.50, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.</footnote>
        <footnote id="F5">This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $54.90 to $55.72, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.</footnote>
        <footnote id="F6">This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $53.57 to $54.07, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.</footnote>
        <footnote id="F7">Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.</footnote>
        <footnote id="F8">This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $53.045 to $54.04, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.</footnote>
        <footnote id="F9">This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $54.05 to $54.85, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.</footnote>
        <footnote id="F10">This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $55.10 to $55.55, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.</footnote>
        <footnote id="F11">This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $54.45 to $55.20, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.</footnote>
        <footnote id="F12">This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $55.45 to $56.40, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.</footnote>
        <footnote id="F13">This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $56.55 to $57.10, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.</footnote>
        <footnote id="F14">David E. Shaw is President and sole shareholder of D. E. Shaw &amp; Co. II, Inc., which is the sole member of D. E. Shaw Technology Development, LLC.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>David E. Shaw, By: /s/ Charles Ardai, as Attorney-in-Fact for David E. Shaw</signatureName>
        <signatureDate>2020-10-09</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Schrodinger Equity Holdings, LLC, By: /s/ Charles Ardai, Authorized Signatory</signatureName>
        <signatureDate>2020-10-09</signatureDate>
    </ownerSignature>
</ownershipDocument>
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  <div><br>
  </div>
  <div>
    <div style="line-height: 0pt;"><br style="line-height: 0pt;">
    </div>
    <div style="text-align: center; line-height: 13.8pt; margin-top: 0.05pt;
color: #000000; font-family: 'Times New Roman'; font-size: 12pt;">APPOINTMENT
AND AUTHORIZATION OF AGENTS</div>
    <div style="text-align: center; line-height: 13.8pt; margin-top: 0.05pt;
color: #000000; font-family: 'Times New Roman'; font-size: 12pt;">AND</div>
    <div style="text-align: center; line-height: 13.8pt; margin-top: 0.05pt;
color: #000000; font-family: 'Times New Roman'; font-size: 12pt;">POWER OF
ATTORNEY</div>
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cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 36pt; vertical-align: top; align: right; color:
#000000; font-family: 'Times New Roman'; font-size: 11pt;">I.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-family: 'Times New Roman'; font-size:
11pt;">Appointment and Authorization of Agents of Schrodinger Equity Holdings,
LLC.</div>
          </td>
        </tr>

    </table>
    <div style="text-indent: 36pt; line-height: 12.55pt; margin-top: 12pt;
margin-bottom: 12pt; font-family: 'Times New Roman'; font-size: 11pt;">Charles
Ardai, acting for Schrodinger Equity Holdings, LLC (the &#8220;LLC&#8221;) in
his capacity as
      authorized agent of the LLC pursuant to that certain Appointment and
Authorization of Agents made by David E. Shaw on January 29, 2020, hereby
constitutes, designates and appoints each of Amantha Butler, Zach Bendiner and
Jennifer McGrady as the
      LLC&#8217;s authorized agent, to:</div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt;
width: 100%; text-align: left; color: #000000; margin-bottom: 12pt; margin-top:
12pt;" class="DSPFListTable" id="z8f567053f9cc4df4bf0d2f1c33a05347"
cellpadding="0" cellspacing="0">

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          <td style="width: 36pt;"><br>
          </td>
          <td style="width: 36pt; vertical-align: top; align: right; color:
#000000; font-family: 'Times New Roman'; font-size: 11pt;">(A)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman';
font-size: 11pt;">execute for and on behalf of the LLC any filings required
under the Securities Act of 1933 (the &#8220;Securities Act&#8221;) or the
Securities Exchange Act of 1934 (the
              &#8220;Exchange Act&#8221;) in connection with the LLC&#8217;s
interests in Schr&#246;dinger, Inc., including without limitation Forms 3, 4 and
5, any filings made pursuant to Rule 144 promulgated under the Securities Act,
and any filings made pursuant to Section
              13(d) or 13(g) of the Exchange Act; and make any communications
with Schr&#246;dinger, Inc. concerning Schr&#246;dinger, Inc.&#8217;s
disclosures pursuant to the Securities Act or the Exchange Act regarding the
LLC&#8217;s interests in Schr&#246;dinger, Inc.;</div>
          </td>
        </tr>

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width: 100%; text-align: left; color: #000000; margin-bottom: 12pt; margin-top:
12pt;" class="DSPFListTable" id="z766ce9e6ccca4884aa43c2f6c7271af0"
cellpadding="0" cellspacing="0">

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          <td style="width: 36pt;"><br>
          </td>
          <td style="width: 36pt; vertical-align: top; align: right; color:
#000000; font-family: 'Times New Roman'; font-size: 11pt;">(B)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman';
font-size: 11pt;">do and perform any and all acts for and on behalf of the LLC
which may be necessary or desirable to complete and execute any filings required
under the Securities Act
              or the Exchange Act in connection with the undersigned&#8217;s
interests in Schr&#246;dinger, Inc.; complete and execute any amendment or
amendments thereto; and timely file such filings with the SEC and any stock
exchange or similar authority; and</div>
          </td>
        </tr>

    </table>
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width: 100%; text-align: left; color: #000000; margin-bottom: 12pt; margin-top:
12pt;" class="DSPFListTable" id="zfb95e737a405445088348380eff47c7a"
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          <td style="width: 36pt; vertical-align: top; align: right; color:
#000000; font-family: 'Times New Roman'; font-size: 11pt;">(C)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman';
font-size: 11pt;">take any other action of any type whatsoever in connection
with the foregoing which, in the opinion of such authorized agent, may be of
benefit to, in the best
              interest of, or legally required of, the LLC, it being understood
that the documents executed by such authorized agent on behalf of the LLC
pursuant to this appointment and authorization shall be in such form and shall
contain such terms and
              conditions as such authorized agent may approve in such authorized
agent&#8217;s discretion.</div>
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          <td style="width: 36pt; vertical-align: top; align: right; color:
#000000; font-family: 'Times New Roman'; font-size: 11pt;">II.</td>
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            <div style="font-family: 'Times New Roman'; font-size: 11pt;">Power
of Attorney.</div>
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    <div style="text-indent: 36pt; line-height: 12.55pt; margin-top: 12pt;
margin-bottom: 12pt; font-family: 'Times New Roman'; font-size: 11pt;">KNOW ALL
PERSONS BY THESE PRESENTS that the undersigned Charles Ardai, acting as
      attorney-in-fact for David E. Shaw (&#8220;Principal&#8221;) pursuant to
that certain power of attorney made on January 29, 2020, hereby constitutes,
designates and appoints each of Amantha Butler, Zach Bendiner and Jennifer
McGrady as such Principal&#8217;s true and
      lawful attorney-in-fact and agent, each with full power of substitution
and resubstitution and full power to act alone, for the Principal and in the
Principal&#8217;s name, place and stead, in any and all capacities, to:</div>
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          <td style="width: 36pt; vertical-align: top; align: right; color:
#000000; font-family: 'Times New Roman'; font-size: 11pt;">(A)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman';
font-size: 11pt;">execute for and on behalf of the Principal any filings
required under the Securities Act or the Exchange Act in connection with the
Principal&#8217;s interests in
              Schr&#246;dinger, Inc., including without limitation Forms 3, 4
and 5, any filings made pursuant to Rule 144 promulgated under the Securities
Act, and any filings made pursuant to Section 13(d) or 13(g) of the Exchange
Act; and make any
              communications with Schr&#246;dinger, Inc. concerning
Schr&#246;dinger, Inc.&#8217;s disclosures pursuant to the Securities Act or the
Exchange Act regarding the Principal&#8217;s interests in Schr&#246;dinger,
Inc.;</div>
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          <td style="width: 36pt; vertical-align: top; align: right; color:
#000000; font-family: 'Times New Roman'; font-size: 11pt;">(B)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman';
font-size: 11pt;">do and perform any and all acts for and on behalf of the
Principal which may be necessary or desirable to complete and execute any
filings required under the
              Securities Act or the Exchange Act in connection with the
Principal&#8217;s interests in Schr&#246;dinger, Inc.; complete and execute any
amendment or amendments thereto; and timely file such filings with the SEC and
any stock exchange or similar
              authority; and</div>
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          <td style="width: 36pt; vertical-align: top; align: right; color:
#000000; font-family: 'Times New Roman'; font-size: 11pt;">(C)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman';
font-size: 11pt;">take any other action of any type whatsoever in connection
with the foregoing which, in the opinion of such attorney-in-fact, may be of
benefit to, in the best
              interest of, or legally required of, the Principal, it being
understood that the documents executed by such attorney-in-fact on behalf of the
Principal pursuant to this Power of Attorney shall be in such form and shall
contain such terms and
              conditions as such attorney-in-fact may approve in such
attorney-in-fact&#8217;s discretion.</div>
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    <div style="text-indent: 36pt; line-height: 12.55pt; margin-top: 12pt;
margin-bottom: 12pt; font-family: 'Times New Roman'; font-size: 11pt;">On behalf
of the Principal, the undersigned hereby grants to each such attorney-in-fact
full
      power and authority to do and perform any and every act and thing
whatsoever requisite, necessary, or proper to be done in the exercise of any of
the rights and powers herein granted, as fully to all intents and purposes as
the Principal might or
      could do if personally present, with full power of substitution or
revocation, hereby ratifying and confirming all that such attorney-in-fact, or
such attorney-in-fact&#8217;s substitute or substitutes, shall lawfully do or
cause to be done by virtue of
      this power of attorney and the rights and powers herein granted. The
undersigned acknowledges that the foregoing attorney-in-fact, in serving in such
capacity at the request of the undersigned, is not assuming any of the
Principal&#8217;s responsibilities
      to comply with Section 16 of the Exchange Act.</div>
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Appointment and Authorization of Agents and Power of Attorney shall remain in
full
      force and effect in each case until revoked by the LLC, the undersigned or
the Principal (as applicable) in a signed writing delivered to the foregoing
agents and attorney-in-fact (as applicable).</div>
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            <div style="line-height: 13.7pt; font-family: 'Times New Roman';
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            <div style="line-height: 13.7pt; font-family: 'Times New Roman';
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          <td style="width: 50%; vertical-align: top;">&#160;</td>
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            <div style="line-height: 13.7pt; font-family: 'Times New Roman';
font-size: 12pt;"><font style="font-weight: bold;">CHARLES ARDAI,
ATTORNEY-IN-FACT</font>&#160;<font style="font-weight: bold;">FOR DAVID E.
SHAW</font></div>
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