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Liquidity, Going Concern and Management Plans (Details Narrative) - USD ($)
$ / shares in Units, $ in Thousands
 3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Dec. 31, 2021
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Cash and Cash Equivalents, at Carrying Value $ 450,922   $ 374,294
Working capital deficit 193,000    
Retained Earnings (Accumulated Deficit) 1,137,335   $ 1,009,293
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest 140,817 $ 70,186  
Proceeds from Issuance of Common Stock 203,765  
Sales Agreement [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Proceeds from Issuance of Common Stock 203,800    
Deduction of commission and expenses $ 4,200    
Stock Issued During Period, Shares, New Issues 27,443,580    
Weighted average gross sale price per share $ 7.58