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v3.25.3

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2025 | Sep. 30, 2024
Cash flows from operating activities |  |
Net loss | $ (174,206) | $ (86,047)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Share-based compensation expense | 20,922 | 12,963
Depreciation expense | 921 | 719
Accretion of asset retirement obligation | 23 | 11
Non-cash lease expense | 1,593 | 1,127
Accretion of net investment discounts | (12,828) | (12,440)
Changes in operating assets and liabilities: |  |
Prepaid expenses and other current assets | (7,286) | (2,080)
Other non-current assets | (1,493) | (1,777)
Accounts payable | 9,772 | 3,730
Accrued expenses and other current liabilities | 6,492 | 4,693
Operating lease liabilities | (1,693) | (1,068)
Net cash used in operating activities | (157,783) | (80,169)
Cash flows from investing activities |  |
Purchases of short-term investments | (453,756) | (570,267)
Proceeds from maturities of short-term investments | 484,372 | 179,400
Purchases of property and equipment | (2,118) | (1,274)
Advance payment received for sale of non-financial asset | 5,158 |
Net cash provided by (used in) investing activities | 33,656 | (392,141)
Cash flows from financing activities |  |
Payments of offering costs | (770) | (1,796)
Proceeds from issuance of ordinary shares under employee share purchase plan | 474 | 241
Proceeds from exercise of share options | 1,385 | 1,630
Payment of taxes on restricted share units withheld for taxes | (618) |
Net cash provided by financing activities | 57,529 | 514,648
Net change in cash and cash equivalents | (66,598) | 42,338
Beginning of the period | 169,510 | 129,792
End of the period | 102,912 | 172,130
Supplemental disclosures of noncash investing and financing activities |  |
Offering costs included in accounts payable and accrued expenses and other current liabilities | 511 | 100
Operating lease right-of-use assets obtained in exchange for new lease liabilities | 4,921 |
Depository issuance cost offset | 1,531 |
ATM Offering |  |
Cash flows from financing activities |  |
Proceeds from issuance of ordinary shares | $ 57,058 |
Follow-On Offering |  |
Cash flows from financing activities |  |
Proceeds from issuance of ordinary shares |  | $ 514,573

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