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CONDENSED CONSOLIDATED STATEMENTS OF SHAREHOLDERS' EQUITY - USD ($) shares in Thousands, $ in Thousands | Common shares Follow-On Offering | Common shares ATM Offering | Common shares | Additional Paid-In Capital Follow-On Offering | Additional Paid-In Capital ATM Offering | Additional Paid-In Capital | Accumulated Other Comprehensive Income (Loss) | Accumulated Deficit | Follow-On Offering | ATM Offering | Total
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Beginning balance at Dec. 31, 2023 |  |  | $ 14 |  |  | $ 659,003 | $ 521 | $ (206,572) |  |  | $ 452,966
Beginning balance (in shares) at Dec. 31, 2023 |  |  | 139,220 |  |  |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |
Issuance of ordinary shares upon exercise of vested share options |  |  |  |  |  | 755 |  |  |  |  | 755
Issuance of ordinary shares upon exercise of vested share options (in shares) |  |  | 635 |  |  |  |  |  |  |  |
Share-based compensation expense |  |  |  |  |  | 2,744 |  |  |  |  | 2,744
Unrealized gain (loss) on investments, net |  |  |  |  |  |  | (611) |  |  |  | (611)
Net loss |  |  |  |  |  |  |  | (26,036) |  |  | (26,036)
Ending balance at Mar. 31, 2024 |  |  | $ 14 |  |  | 662,502 | (90) | (232,608) |  |  | 429,818
Ending balance (in shares) at Mar. 31, 2024 |  |  | 139,855 |  |  |  |  |  |  |  |
Beginning balance at Dec. 31, 2023 |  |  | $ 14 |  |  | 659,003 | 521 | (206,572) |  |  | 452,966
Beginning balance (in shares) at Dec. 31, 2023 |  |  | 139,220 |  |  |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |
Unrealized gain (loss) on investments, net |  |  |  |  |  |  |  |  |  |  | 2,318
Net loss |  |  |  |  |  |  |  |  |  |  | (86,047)
Ending balance at Sep. 30, 2024 |  |  | $ 17 |  |  | 1,186,564 | 2,839 | (292,619) |  |  | 896,801
Ending balance (in shares) at Sep. 30, 2024 |  |  | 171,762 |  |  |  |  |  |  |  |
Beginning balance at Mar. 31, 2024 |  |  | $ 14 |  |  | 662,502 | (90) | (232,608) |  |  | 429,818
Beginning balance (in shares) at Mar. 31, 2024 |  |  | 139,855 |  |  |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |
Issuance of ordinary shares | $ 3 |  |  | $ 512,727 |  |  |  |  | $ 512,730 |  |
Issuance of ordinary shares (in shares) | 31,281 |  |  |  |  |  |  |  |  |  |
Issuance of ordinary shares upon exercise of vested share options |  |  |  |  |  | 478 |  |  |  |  | 478
Issuance of ordinary shares upon exercise of vested share options (in shares) |  |  | 427 |  |  |  |  |  |  |  |
Issuance of ordinary shares pursuant to employee share purchase plan |  |  |  |  |  | 241 |  |  |  |  | 241
Issuance of ordinary shares pursuant to employee share purchase plan (in shares) |  |  | 26 |  |  |  |  |  |  |  |
Share-based compensation expense |  |  |  |  |  | 4,196 |  |  |  |  | 4,196
Unrealized gain (loss) on investments, net |  |  |  |  |  |  | (397) |  |  |  | (397)
Net loss |  |  |  |  |  |  |  | (26,034) |  |  | (26,034)
Ending balance at Jun. 30, 2024 |  |  | $ 17 |  |  | 1,180,144 | (487) | (258,642) |  |  | 921,032
Ending balance (in shares) at Jun. 30, 2024 |  |  | 171,589 |  |  |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |
Issuance of ordinary shares upon exercise of vested share options |  |  |  |  |  | 397 |  |  |  |  | 397
Issuance of ordinary shares upon exercise of vested share options (in shares) |  |  | 166 |  |  |  |  |  |  |  |
Issuance of ordinary shares upon vesting of restricted share units (in shares) |  |  | 7 |  |  |  |  |  |  |  |
Share-based compensation expense |  |  |  |  |  | 6,023 |  |  |  |  | 6,023
Unrealized gain (loss) on investments, net |  |  |  |  |  |  | 3,326 |  |  |  | 3,326
Net loss |  |  |  |  |  |  |  | (33,977) |  |  | (33,977)
Ending balance at Sep. 30, 2024 |  |  | $ 17 |  |  | 1,186,564 | 2,839 | (292,619) |  |  | 896,801
Ending balance (in shares) at Sep. 30, 2024 |  |  | 171,762 |  |  |  |  |  |  |  |
Beginning balance at Dec. 31, 2024 |  |  | $ 17 |  |  | 1,193,010 | 914 | (329,098) |  |  | 864,843
Beginning balance (in shares) at Dec. 31, 2024 |  |  | 171,860 |  |  |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |
Issuance of ordinary shares upon exercise of vested share options |  |  |  |  |  | 965 |  |  |  |  | 965
Issuance of ordinary shares upon exercise of vested share options (in shares) |  |  | 644 |  |  |  |  |  |  |  |
Issuance of ordinary shares upon vesting of restricted share units (in shares) |  |  | 134 |  |  |  |  |  |  |  |
Shares withheld for taxes |  |  |  |  |  | (156) |  |  |  |  | (156)
Shares withheld for taxes (in shares) |  |  | (28) |  |  |  |  |  |  |  |
Share-based compensation expense |  |  |  |  |  | 5,918 |  |  |  |  | 5,918
Unrealized gain (loss) on investments, net |  |  |  |  |  |  | (99) |  |  |  | (99)
Net loss |  |  |  |  |  |  |  | (46,833) |  |  | (46,833)
Ending balance at Mar. 31, 2025 |  |  | $ 17 |  |  | 1,199,737 | 815 | (375,931) |  |  | 824,638
Ending balance (in shares) at Mar. 31, 2025 |  |  | 172,610 |  |  |  |  |  |  |  |
Beginning balance at Dec. 31, 2024 |  |  | $ 17 |  |  | 1,193,010 | 914 | (329,098) |  |  | 864,843
Beginning balance (in shares) at Dec. 31, 2024 |  |  | 171,860 |  |  |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |
Unrealized gain (loss) on investments, net |  |  |  |  |  |  |  |  |  |  | (89)
Net loss |  |  |  |  |  |  |  |  |  |  | (174,206)
Ending balance at Sep. 30, 2025 |  |  | $ 18 |  |  | 1,272,480 | 825 | (503,304) |  |  | 770,019
Ending balance (in shares) at Sep. 30, 2025 |  |  | 182,033 |  |  |  |  |  |  |  |
Beginning balance at Mar. 31, 2025 |  |  | $ 17 |  |  | 1,199,737 | 815 | (375,931) |  |  | 824,638
Beginning balance (in shares) at Mar. 31, 2025 |  |  | 172,610 |  |  |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |
Issuance of ordinary shares upon exercise of vested share options |  |  |  |  |  | 43 |  |  |  |  | 43
Issuance of ordinary shares upon exercise of vested share options (in shares) |  |  | 22 |  |  |  |  |  |  |  |
Issuance of ordinary shares pursuant to employee share purchase plan |  |  |  |  |  | 474 |  |  |  |  | 474
Issuance of ordinary shares pursuant to employee share purchase plan (in shares) |  |  | 68 |  |  |  |  |  |  |  |
Depository issuance cost offset |  |  |  |  |  | 1,531 |  |  |  |  | 1,531
Share-based compensation expense |  |  |  |  |  | 7,509 |  |  |  |  | 7,509
Unrealized gain (loss) on investments, net |  |  |  |  |  |  | (453) |  |  |  | (453)
Net loss |  |  |  |  |  |  |  | (61,661) |  |  | (61,661)
Ending balance at Jun. 30, 2025 |  |  | $ 17 |  |  | 1,209,294 | 362 | (437,592) |  |  | 772,081
Ending balance (in shares) at Jun. 30, 2025 |  |  | 172,700 |  |  |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |
Issuance of ordinary shares |  | $ 1 |  |  | $ 55,776 |  |  |  |  | $ 55,777 |
Issuance of ordinary shares (in shares) |  | 9,120 |  |  |  |  |  |  |  |  |
Issuance of ordinary shares upon exercise of vested share options |  |  |  |  |  | 377 |  |  |  |  | 377
Issuance of ordinary shares upon exercise of vested share options (in shares) |  |  | 95 |  |  |  |  |  |  |  |
Issuance of ordinary shares upon vesting of restricted share units (in shares) |  |  | 55 |  |  |  |  |  |  |  |
Issuance of ordinary shares upon vesting of performance share units (in Shares) |  |  | 118 |  |  |  |  |  |  |  |
Shares withheld for taxes |  |  |  |  |  | (462) |  |  |  |  | (462)
Shares withheld for taxes (in shares) |  |  | (55) |  |  |  |  |  |  |  |
Share-based compensation expense |  |  |  |  |  | 7,495 |  |  |  |  | 7,495
Unrealized gain (loss) on investments, net |  |  |  |  |  |  | 463 |  |  |  | 463
Net loss |  |  |  |  |  |  |  | (65,712) |  |  | (65,712)
Ending balance at Sep. 30, 2025 |  |  | $ 18 |  |  | $ 1,272,480 | $ 825 | $ (503,304) |  |  | $ 770,019
Ending balance (in shares) at Sep. 30, 2025 |  |  | 182,033 |  |  |  |  |  |  |  |

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