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v3.25.3

Summary of Significant Accounting Policies - Segments (Details) $ in Thousands | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2025 USD ($) | Jun. 30, 2025 USD ($) | Mar. 31, 2025 USD ($) | Sep. 30, 2024 USD ($) | Jun. 30, 2024 USD ($) | Mar. 31, 2024 USD ($) | Sep. 30, 2025 USD ($) segment | Sep. 30, 2024 USD ($)
Summary of Significant Accounting Policies |  |  |  |  |  |  |  |
Number of Reportable Segments | segment |  |  |  |  |  |  | 1 |
Number of operating segments | segment |  |  |  |  |  |  | 1 |
Operating expenses: |  |  |  |  |  |  |  |
General and administrative | $ 14,798 |  |  | $ 13,238 |  |  | $ 43,983 | $ 35,840
Total operating expenses | 73,787 |  |  | 45,836 |  |  | 200,549 | 111,167
Loss from operations | (73,787) |  |  | (45,836) |  |  | (200,549) | (111,167)
Interest and other income, net | 8,183 |  |  | 11,951 |  |  | 26,688 | 25,294
Loss before provision for income taxes | (65,604) |  |  | (33,885) |  |  | (173,861) | (85,873)
Provision for income taxes | 108 |  |  | 92 |  |  | 345 | 174
Net loss attributable to ordinary shareholders | (65,712) | $ (61,661) | $ (46,833) | (33,977) | $ (26,034) | $ (26,036) | (174,206) | (86,047)
Single Reporting Segment |  |  |  |  |  |  |  |
Operating expenses: |  |  |  |  |  |  |  |
Discovery research and development | 24,602 |  |  | 17,417 |  |  | 72,633 | 37,809
Clinical research and development | 28,647 |  |  | 11,811 |  |  | 68,953 | 29,507
Other research and development expenses | 5,740 |  |  | 3,370 |  |  | 14,980 | 8,011
General and administrative | 14,798 |  |  | 13,238 |  |  | 43,983 | 35,840
Total operating expenses | 73,787 |  |  | 45,836 |  |  | 200,549 | 111,167
Loss from operations | (73,787) |  |  | (45,836) |  |  | (200,549) | (111,167)
Interest and other income, net | 8,183 |  |  | 11,951 |  |  | 26,688 | 25,294
Loss before provision for income taxes | (65,604) |  |  | (33,885) |  |  | (173,861) | (85,873)
Provision for income taxes | 108 |  |  | 92 |  |  | 345 | 174
Net loss attributable to ordinary shareholders | $ (65,712) |  |  | $ (33,977) |  |  | $ (174,206) | $ (86,047)

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