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Summary of Significant Accounting Policies - Segments (Details)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2025
USD ($)
Jun. 30, 2025
USD ($)
Mar. 31, 2025
USD ($)
Sep. 30, 2024
USD ($)
Jun. 30, 2024
USD ($)
Mar. 31, 2024
USD ($)
Sep. 30, 2025
USD ($)
segment
Sep. 30, 2024
USD ($)
Summary of Significant Accounting Policies                
Number of Reportable Segments | segment             1  
Number of operating segments | segment             1  
Operating expenses:                
General and administrative $ 14,798     $ 13,238     $ 43,983 $ 35,840
Total operating expenses 73,787     45,836     200,549 111,167
Loss from operations (73,787)     (45,836)     (200,549) (111,167)
Interest and other income, net 8,183     11,951     26,688 25,294
Loss before provision for income taxes (65,604)     (33,885)     (173,861) (85,873)
Provision for income taxes 108     92     345 174
Net loss attributable to ordinary shareholders (65,712) $ (61,661) $ (46,833) (33,977) $ (26,034) $ (26,036) (174,206) (86,047)
Single Reporting Segment                
Operating expenses:                
Discovery research and development 24,602     17,417     72,633 37,809
Clinical research and development 28,647     11,811     68,953 29,507
Other research and development expenses 5,740     3,370     14,980 8,011
General and administrative 14,798     13,238     43,983 35,840
Total operating expenses 73,787     45,836     200,549 111,167
Loss from operations (73,787)     (45,836)     (200,549) (111,167)
Interest and other income, net 8,183     11,951     26,688 25,294
Loss before provision for income taxes (65,604)     (33,885)     (173,861) (85,873)
Provision for income taxes 108     92     345 174
Net loss attributable to ordinary shareholders $ (65,712)     $ (33,977)     $ (174,206) $ (86,047)