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CONDENSED CONSOLIDATED STATEMENTS OF SHAREHOLDERS' EQUITY - USD ($)
shares in Thousands, $ in Thousands
Common shares
Follow-On Offering
Common shares
ATM Offering
Common shares
Additional Paid-In Capital
Follow-On Offering
Additional Paid-In Capital
ATM Offering
Additional Paid-In Capital
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Follow-On Offering
ATM Offering
Total
Beginning balance at Dec. 31, 2023     $ 14     $ 659,003 $ 521 $ (206,572)     $ 452,966
Beginning balance (in shares) at Dec. 31, 2023     139,220                
Increase (Decrease) in Stockholders' Equity [Roll Forward]                      
Issuance of ordinary shares upon exercise of vested share options           755         755
Issuance of ordinary shares upon exercise of vested share options (in shares)     635                
Share-based compensation expense           2,744         2,744
Unrealized gain (loss) on investments, net             (611)       (611)
Net loss               (26,036)     (26,036)
Ending balance at Mar. 31, 2024     $ 14     662,502 (90) (232,608)     429,818
Ending balance (in shares) at Mar. 31, 2024     139,855                
Beginning balance at Dec. 31, 2023     $ 14     659,003 521 (206,572)     452,966
Beginning balance (in shares) at Dec. 31, 2023     139,220                
Increase (Decrease) in Stockholders' Equity [Roll Forward]                      
Unrealized gain (loss) on investments, net                     2,318
Net loss                     (86,047)
Ending balance at Sep. 30, 2024     $ 17     1,186,564 2,839 (292,619)     896,801
Ending balance (in shares) at Sep. 30, 2024     171,762                
Beginning balance at Mar. 31, 2024     $ 14     662,502 (90) (232,608)     429,818
Beginning balance (in shares) at Mar. 31, 2024     139,855                
Increase (Decrease) in Stockholders' Equity [Roll Forward]                      
Issuance of ordinary shares $ 3     $ 512,727         $ 512,730    
Issuance of ordinary shares (in shares) 31,281                    
Issuance of ordinary shares upon exercise of vested share options           478         478
Issuance of ordinary shares upon exercise of vested share options (in shares)     427                
Issuance of ordinary shares pursuant to employee share purchase plan           241         241
Issuance of ordinary shares pursuant to employee share purchase plan (in shares)     26                
Share-based compensation expense           4,196         4,196
Unrealized gain (loss) on investments, net             (397)       (397)
Net loss               (26,034)     (26,034)
Ending balance at Jun. 30, 2024     $ 17     1,180,144 (487) (258,642)     921,032
Ending balance (in shares) at Jun. 30, 2024     171,589                
Increase (Decrease) in Stockholders' Equity [Roll Forward]                      
Issuance of ordinary shares upon exercise of vested share options           397         397
Issuance of ordinary shares upon exercise of vested share options (in shares)     166                
Issuance of ordinary shares upon vesting of restricted share units (in shares)     7                
Share-based compensation expense           6,023         6,023
Unrealized gain (loss) on investments, net             3,326       3,326
Net loss               (33,977)     (33,977)
Ending balance at Sep. 30, 2024     $ 17     1,186,564 2,839 (292,619)     896,801
Ending balance (in shares) at Sep. 30, 2024     171,762                
Beginning balance at Dec. 31, 2024     $ 17     1,193,010 914 (329,098)     864,843
Beginning balance (in shares) at Dec. 31, 2024     171,860                
Increase (Decrease) in Stockholders' Equity [Roll Forward]                      
Issuance of ordinary shares upon exercise of vested share options           965         965
Issuance of ordinary shares upon exercise of vested share options (in shares)     644                
Issuance of ordinary shares upon vesting of restricted share units (in shares)     134                
Shares withheld for taxes           (156)         (156)
Shares withheld for taxes (in shares)     (28)                
Share-based compensation expense           5,918         5,918
Unrealized gain (loss) on investments, net             (99)       (99)
Net loss               (46,833)     (46,833)
Ending balance at Mar. 31, 2025     $ 17     1,199,737 815 (375,931)     824,638
Ending balance (in shares) at Mar. 31, 2025     172,610                
Beginning balance at Dec. 31, 2024     $ 17     1,193,010 914 (329,098)     864,843
Beginning balance (in shares) at Dec. 31, 2024     171,860                
Increase (Decrease) in Stockholders' Equity [Roll Forward]                      
Unrealized gain (loss) on investments, net                     (89)
Net loss                     (174,206)
Ending balance at Sep. 30, 2025     $ 18     1,272,480 825 (503,304)     770,019
Ending balance (in shares) at Sep. 30, 2025     182,033                
Beginning balance at Mar. 31, 2025     $ 17     1,199,737 815 (375,931)     824,638
Beginning balance (in shares) at Mar. 31, 2025     172,610                
Increase (Decrease) in Stockholders' Equity [Roll Forward]                      
Issuance of ordinary shares upon exercise of vested share options           43         43
Issuance of ordinary shares upon exercise of vested share options (in shares)     22                
Issuance of ordinary shares pursuant to employee share purchase plan           474         474
Issuance of ordinary shares pursuant to employee share purchase plan (in shares)     68                
Depository issuance cost offset           1,531         1,531
Share-based compensation expense           7,509         7,509
Unrealized gain (loss) on investments, net             (453)       (453)
Net loss               (61,661)     (61,661)
Ending balance at Jun. 30, 2025     $ 17     1,209,294 362 (437,592)     772,081
Ending balance (in shares) at Jun. 30, 2025     172,700                
Increase (Decrease) in Stockholders' Equity [Roll Forward]                      
Issuance of ordinary shares   $ 1     $ 55,776         $ 55,777  
Issuance of ordinary shares (in shares)   9,120                  
Issuance of ordinary shares upon exercise of vested share options           377         377
Issuance of ordinary shares upon exercise of vested share options (in shares)     95                
Issuance of ordinary shares upon vesting of restricted share units (in shares)     55                
Issuance of ordinary shares upon vesting of performance share units (in Shares)     118                
Shares withheld for taxes           (462)         (462)
Shares withheld for taxes (in shares)     (55)                
Share-based compensation expense           7,495         7,495
Unrealized gain (loss) on investments, net             463       463
Net loss               (65,712)     (65,712)
Ending balance at Sep. 30, 2025     $ 18     $ 1,272,480 $ 825 $ (503,304)     $ 770,019
Ending balance (in shares) at Sep. 30, 2025     182,033