<SEC-DOCUMENT>0001415889-25-019354.txt : 20250703
<SEC-HEADER>0001415889-25-019354.hdr.sgml : 20250703
<ACCEPTANCE-DATETIME>20250703171514
ACCESSION NUMBER:		0001415889-25-019354
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20250301
FILED AS OF DATE:		20250703
DATE AS OF CHANGE:		20250703

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Coll Crespo Blas
		CENTRAL INDEX KEY:			0002037144
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-41608
		FILM NUMBER:		251106360

	MAIL ADDRESS:	
		STREET 1:		C/O STRUCTURE THERAPEUTICS INC.
		STREET 2:		601 GATEWAY BLVD., SUITE 900
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080

	FORMER NAME:	
		FORMER CONFORMED NAME:	Crespo Blas Coll
		DATE OF NAME CHANGE:	20240911

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Structure Therapeutics Inc.
		CENTRAL INDEX KEY:			0001888886
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				981480821
		STATE OF INCORPORATION:			E9
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		611 GATEWAY BLVD SUITE 223
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
		BUSINESS PHONE:		(628) 229-9277

	MAIL ADDRESS:	
		STREET 1:		611 GATEWAY BLVD SUITE 223
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ShouTi Inc.
		DATE OF NAME CHANGE:	20211019
</SEC-HEADER>
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    <periodOfReport>2025-03-01</periodOfReport>

    <issuer>
        <issuerCik>0001888886</issuerCik>
        <issuerName>Structure Therapeutics Inc.</issuerName>
        <issuerTradingSymbol>GPCR</issuerTradingSymbol>
    </issuer>

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            <rptOwnerCik>0002037144</rptOwnerCik>
            <rptOwnerName>Coll Crespo Blas</rptOwnerName>
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            <rptOwnerStreet1>C/O STRUCTURE THERAPEUTICS INC.</rptOwnerStreet1>
            <rptOwnerStreet2>601 GATEWAY BLVD., SUITE 900</rptOwnerStreet2>
            <rptOwnerCity>SOUTH SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94080</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>false</isDirector>
            <isOfficer>true</isOfficer>
            <isTenPercentOwner>false</isTenPercentOwner>
            <isOther>false</isOther>
            <officerTitle>CHIEF MEDICAL OFFICER</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

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                <transactionPricePerShare>
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        </nonDerivativeTransaction>
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    <derivativeTable>
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            <conversionOrExercisePrice>
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            <transactionAmounts>
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                </transactionShares>
                <transactionPricePerShare>
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                <transactionAcquiredDisposedCode>
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            <exerciseDate>
                <footnoteId id="F4"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F4"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Ordinary Shares</value>
                    <footnoteId id="F1"/>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>1287</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
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                <sharesOwnedFollowingTransaction>
                    <value>1157</value>
                </sharesOwnedFollowingTransaction>
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                    <value></value>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeTransaction>
        <derivativeHolding>
            <securityTitle>
                <value>American Depositary Shares</value>
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            <underlyingSecurity>
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                    <footnoteId id="F1"/>
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                </underlyingSecurityShares>
            </underlyingSecurity>
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                <sharesOwnedFollowingTransaction>
                    <value>1000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By spouse</value>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
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    <footnotes>
        <footnote id="F1">The Ordinary Shares of the Issuer may be represented by American Depositary Shares (&quot;ADSs&quot;). Each ADS represents three Ordinary Shares of the Issuer.</footnote>
        <footnote id="F2">Represents shares withheld by the Issuer to satisfy income tax obligations associated with the vesting of a restricted share unit award.</footnote>
        <footnote id="F3">On March 15, 2024, the reporting person was granted performance-vesting restricted share units (&quot;PSUs&quot;), each of which represents a contingent right to receive one Ordinary Share of the Issuer, which vest upon satisfaction of certain performance criteria.  Certain of the performance criteria was determined to have been met effective July 1, 2025.  The shares subject to the PSUs vest as follows:  50% of the shares vested on July 1, 2025 and the remainder will vest on January 1, 2027 subject to the reporting person's Continuous Service (as defined in the Structure Therapeutics Inc. 2023 Equity Incentive Plan) through such vesting date.</footnote>
        <footnote id="F4">Each ADS is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The ADSs have no expiration date.</footnote>
        <footnote id="F5">Voluntary reporting of the acquisition of 429 ADSs by the Reporting Person on May 21, 2025 pursuant to the Issuer's Employee Share Purchase Plan.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Jun Yoon, Attorney-in-Fact</signatureName>
        <signatureDate>2025-07-03</signatureDate>
    </ownerSignature>
</ownershipDocument>
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</SEC-DOCUMENT>
