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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2022 | Sep. 30, 2021
Cash flows used in operating activities: |  |
Net loss | $ (82,134) | $ (147,644)
Adjustments to reconcile net loss to net cash used in operating activities |  |
Depreciation and amortization | 2,487 | 2,030
Upfront license and milestone expense | 0 | 10,000
Share-based compensation expense | 25,398 | 22,666
Inventory write-down | 2,464 | 0
Other, net | 587 | 1,005
Net changes in operating assets and liabilities |  |
Accounts receivable | (26,356) | (9,815)
Inventories, net | (8,458) | (5,366)
Prepaid expenses and other current assets | (3,461) | (6,541)
Non-current assets | (830) | 247
Accounts payable, accrued and other liabilities | 875 | 1,149
Lease liabilities | (551) | 499
Net cash used in operating activities | (89,979) | (131,770)
Cash flows used in investing activities: |  |
Purchase of investments | (403,184) | (342,831)
Proceeds from investments | 346,109 | 263,752
Upfront lease payment | (381) | (11,838)
Upfront license payment | 0 | (6,000)
Purchase of non-current assets | (158) | (268)
Additions to internal use-software implementation costs | 0 | (1,198)
Net cash used in investing activities | (57,614) | (98,383)
Cash flows from financing activities |  |
Proceeds from exercise of stock options and employee share purchase plan | 1,745 | 15,353
Proceeds from exercise of warrants | 0 | 37
Cash provided by financing activities | 1,745 | 15,390
Net decrease in cash, cash equivalents and restricted cash | (145,848) | (214,763)
Cash, cash equivalents and restricted cash, beginning of period | 231,900 | 272,350
Cash, cash equivalents and restricted cash, end of period | 86,052 | 57,587
Supplemental cash flow information |  |
Cash received for interest | 1,705 | 671
Cash paid for taxes | (779) | (236)
Cash paid for amounts included in the measurement of lease liabilities | (897) | (195)
Supplemental disclosure of noncash transactions |  |
Initial recognition of operating lease right-of-use asset | 0 | 419
Reconciliation of cash, cash equivalents and restricted cash to the condensed consolidated balance sheets |  |
Cash, cash equivalents | 85,341 | 57,587
Restricted cash | 711 | 0
Total cash, cash equivalents and restricted cash | $ 86,052 | $ 57,587

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