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Pay vs Performance Disclosure - USD ($) | 12 Months Ended
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Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Pay vs Performance Disclosure |  |  |  |
Pay vs Performance Disclosure, Table |
Year | Summary Compensation Table Total for PEO(1) ($) | Compensation Actually Paid to PEO(1)˒(2)˒(3) ($) | Average Summary Compensation Table Total for Non-PEO NEOs(1) ($) | Average Compensation Actually Paid to Non-PEO NEOs(1),(2),(3) ($) | Value of Initial Fixed $100 Investment based on:(4) | Net Income ($ Millions) | Net Revenue(5) ($ Millions)
TSR ($) | Peer Group TSR ($)
(a) | (b) | (c) | (d) | (e) | (f) | (g) | (h) | (i)
2023 | 10,573,359 | 14,915,528 | 3,892,438 | 5,271,052 | 44.37 | 115.42 | (78) | 176
2022 | 8,837,397 | (8,899,595) | 3,275,710 | (748,376) | 21.32 | 113.65 | (108) | 134
2021 | 1,240,389 | 16,344,707 | 718,163 | 4,188,759 | 112.88 | 126.45 | (181) | 46
2020 | 10,678,868 | (2,601,908) | 3,233,747 | 2,545,959 | 68.26 | 126.42 | (103) | 50
Company Selected Measure Name | Net Revenue |  |  |
Named Executive Officers, Footnote | Peter Greenleaf was our PEO for each year presented. |  |  |
Peer Group Issuers, Footnote | The Peer Group TSR set forth in this table utilizes the NASDAQ Biotechnology Index, which we also utilize in the stock performance graph required by Item 201(e) of Regulation S-K included in our Annual Report for the year ended December 31, 2023. The comparison assumes $100 was invested for the period starting December 31, 2020, through the end of the listed year in the Company and in the NASDAQ Biotechnology Index, respectively. Historical stock performance is not necessarily indicative of future stock performance. |  |  |
PEO Total Compensation Amount | $ 10,573,359 | $ 8,837,397 | $ 1,240,389 | $ 10,678,868
PEO Actually Paid Compensation Amount | $ 14,915,528 | (8,899,595) | 16,344,707 | (2,601,908)
Adjustment To PEO Compensation, Footnote | Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEO and the Non-PEO NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock Awards and Option Awards column are the totals from the Stock Awards and Option Awards columns set forth in the Summary Compensation Table. Reconciliation of Summary Compensation Table to Compensation Actually Paid Calculation
Year | Summary Compensation Table Total for Peter Greenleaf ($) | Exclusion of Stock Awards and Option Awards for Peter Greenleaf ($) | Inclusion of Equity Values for Peter Greenleaf ($) | Compensation Actually Paid to Peter Greenleaf ($)
2023 | 10,573,359 | (8,999,997) | 13,342,166 | 14,915,528
2022 | 8,837,397 | (7,502,011) | (10,234,980) | (8,899,595)
2021 | 1,240,389 | — | 15,104,318 | 16,344,707
2020 | 10,678,868 | (9,288,898) | (3,991,878) | (2,601,908)
Year | Average Summary Compensation Table Total for Non-PEO NEOs ($) | Average Exclusion of Stock Awards and Option Awards for Non-PEO NEOs ($) | Average Inclusion of Equity Values for Non-PEO NEOs ($) | Average Compensation Actually Paid to Non-PEO NEOs ($)
2023 | 3,892,438 | (3,023,431) | 4,402,045 | 5,271,052
2022 | 3,275,710 | (2,375,417) | (1,648,669) | (748,376)
2021 | 718,163 | — | 3,470,596 | 4,188,759
2020 | 3,233,747 | (2,741,071) | 2,053,283 | 2,545,959
Non-PEO NEO Average Total Compensation Amount | $ 3,892,438 | 3,275,710 | 718,163 | 3,233,747
Non-PEO NEO Average Compensation Actually Paid Amount | $ 5,271,052 | (748,376) | 4,188,759 | 2,545,959
Adjustment to Non-PEO NEO Compensation Footnote | The individuals comprising the Non-PEO NEOs for each year presented are listed below. For 2022, 2021 and 2020, please see respective proxy statements for assumptions and details.
2023 | 2022 | 2021 | 2020
Joe Miller | Joe Miller | Joe Miller | Joe Miller
Max Donley | Max Colao | Max Colao | Dennis Bourgeault
Stephen Robertson | Max Donley | Max Donley | Max Colao
Volker Knappertz | Stephen Robertson | Stephen Robertson | Max Donley
| Volker Knappertz |  | Stephen Robertson
| Neil Solomons |  |
Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEO and the Non-PEO NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock Awards and Option Awards column are the totals from the Stock Awards and Option Awards columns set forth in the Summary Compensation Table. Reconciliation of Summary Compensation Table to Compensation Actually Paid Calculation
Year | Summary Compensation Table Total for Peter Greenleaf ($) | Exclusion of Stock Awards and Option Awards for Peter Greenleaf ($) | Inclusion of Equity Values for Peter Greenleaf ($) | Compensation Actually Paid to Peter Greenleaf ($)
2023 | 10,573,359 | (8,999,997) | 13,342,166 | 14,915,528
2022 | 8,837,397 | (7,502,011) | (10,234,980) | (8,899,595)
2021 | 1,240,389 | — | 15,104,318 | 16,344,707
2020 | 10,678,868 | (9,288,898) | (3,991,878) | (2,601,908)
Year | Average Summary Compensation Table Total for Non-PEO NEOs ($) | Average Exclusion of Stock Awards and Option Awards for Non-PEO NEOs ($) | Average Inclusion of Equity Values for Non-PEO NEOs ($) | Average Compensation Actually Paid to Non-PEO NEOs ($)
2023 | 3,892,438 | (3,023,431) | 4,402,045 | 5,271,052
2022 | 3,275,710 | (2,375,417) | (1,648,669) | (748,376)
2021 | 718,163 | — | 3,470,596 | 4,188,759
2020 | 3,233,747 | (2,741,071) | 2,053,283 | 2,545,959
Compensation Actually Paid vs. Total Shareholder Return |  |  |  |
Compensation Actually Paid vs. Net Income |  |  |  |
Tabular List, Table | List of Most Important Financial Performance Measures Net Revenue was the sole financial performance measure that the Company used in linking Compensation Actually Paid to our PEO and other NEOs for 2023 to Company performance. |  |  |
Total Shareholder Return Amount | $ 44.37 | 21.32 | 112.88 | 68.26
Peer Group Total Shareholder Return Amount | 115.42 | 113.65 | 126.45 | 126.42
Net Income (Loss) | $ (78,000,000) | $ (108,000,000) | $ (181,000,000) | $ (103,000,000)
Company Selected Measure Amount | 176,000,000 | 134,000,000 | 46,000,000 | 50,000,000
PEO Name | Peter Greenleaf |  |  |
Additional 402(v) Disclosure | The amounts shown for Compensation Actually Paid have been calculated in accordance with Item 402(v) of Regulation S-K and do not reflect compensation actually earned, realized, or received by the Company’s NEOs. These amounts reflect the Summary Compensation Table Total with certain adjustments as described in footnote 3 below.We determined Net Revenue to be the most important financial performance measure used to link Company performance to Compensation Actually Paid to our PEO and Non-PEO NEOs in 2023. This performance measure may not have been the most important financial performance measure for years 2021 and 2020 and we may determine a different financial performance measure to be the most important financial performance measure in future years. |  |  |
Measure:: 1 |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Compensation Actually Paid vs. Other Measure |  |  |  |
PEO | Measure:: 1 |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Name | Net Revenue |  |  |
PEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | $ (8,999,997) | $ (7,502,011) | $ 0 | $ (9,288,898)
PEO | Equity Awards Adjustments, Excluding Value Reported in Compensation Table |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | 13,342,166 | (10,234,980) | 15,104,318 | (3,991,878)
PEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | 8,999,997 | 2,799,360 | 0 | 7,762,704
PEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | 1,566,255 | (5,421,035) | 10,202,439 | (7,270,230)
PEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | 0 | 0 | 0 | 0
PEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | 2,775,914 | (7,613,305) | 4,901,879 | (4,484,352)
PEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | 0 | 0 | 0 | 0
PEO | Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | $ 0 | 0 | 0 | 0
Non-PEO NEO | Measure:: 1 |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Name | Net Revenue |  |  |
Non-PEO NEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | $ (3,023,431) | (2,375,417) | 0 | (2,741,071)
Non-PEO NEO | Equity Awards Adjustments, Excluding Value Reported in Compensation Table |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | 4,402,045 | (1,648,669) | 3,470,596 | 2,053,283
Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | 3,023,431 | 701,513 | 0 | 2,449,340
Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | 616,428 | (656,801) | 2,255,191 | (235,061)
Non-PEO NEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | 0 | 0 | 0 | 95,426
Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | 762,186 | (941,151) | 1,215,405 | (256,422)
Non-PEO NEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | 0 | (752,230) | 0 | 0
Non-PEO NEO | Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | $ 0 | $ 0 | $ 0 | $ 0

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