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v3.25.4

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2025 | Dec. 31, 2024 | Dec. 31, 2023
Cash flows from operating activities: |  |  |
Net loss | $ (146,412) | $ (162,857) | $ (146,398)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation of property and equipment | 18,439 | 12,537 | 12,758
Amortization and impairment of intangible assets | 3,732 | 78,312 | 11,637
Amortization of operating lease right-of-use assets | 6,650 | 6,149 | 6,499
Stock-based compensation | 55,792 | 67,581 | 64,183
Fair value (gain) loss on contingent consideration and investments | 4,529 | (64,727) | (8,018)
Other | (3,331) | (19,708) | 2,237
Changes in operating assets and liabilities: |  |  |
Research fees and grants receivable | (55,623) | (75,119) | (45,933)
Income taxes (payable) receivable | (29,843) | 6,651 | 30,464
Accounts payable and accrued liabilities | 3,457 | 10,635 | (15,104)
Deferred revenue | (2,195) | (7,931) | (13,976)
Deferred grant income | (3,638) | 33,967 | 39,521
Other assets | 17,148 | 5,954 | 18,253
Net cash used in operating activities | (131,295) | (108,556) | (43,877)
Cash flows from investing activities: |  |  |
Purchases of property and equipment | (42,772) | (78,396) | (76,947)
Purchase of marketable securities | (436,044) | (765,086) | (1,021,510)
Proceeds from marketable securities | 506,072 | 937,882 | 910,937
Receipt of grant funding | 21,343 | 35,708 | 25,311
Distribution from equity accounted investees | 30,113 | 0 | 0
Investment in and loans to equity accounted investees | (7,137) | (19,626) | (13,690)
Proceeds from repayment of loan from joint venture partner | 33,268 | 0 | 0
Long-term investments and other assets | (17,093) | 10,927 | (45,209)
Net cash provided by (used in) investing activities | 87,750 | 121,409 | (221,108)
Cash flows from financing activities: |  |  |
Payment of liability for in-licensing agreement and other | (15,649) | (729) | (1,234)
Proceeds from long-term liabilities and other | 29,731 | 13,498 | 11,590
Net cash provided by financing activities | 14,082 | 12,769 | 10,356
Effect of exchange rate changes on cash and cash equivalents | 1,097 | (2,617) | 589
Increase (decrease) in cash and cash equivalents | (28,366) | 23,005 | (254,040)
Cash and cash equivalents and restricted cash, beginning of period | 183,615 | 160,610 | 414,650
Cash and cash equivalents and restricted cash, end of period | 155,249 | 183,615 | 160,610
Restricted cash included in other assets | 1,736 | 2,290 | 2,290
Total cash, cash equivalents, and restricted cash shown on the balance sheet | 153,513 | 181,325 | 158,320
Supplemental disclosure of non-cash investing and financing activities |  |  |
Property and equipment in accounts payable | 1,995 | 12,767 | 13,625
Right-of-use assets obtained in exchange for operating lease obligation | $ 76,118 | $ 1,898 | $ 1,199

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