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Commitments and Contingencies - Additional Information (Detail) | 3 Months Ended | 9 Months Ended |  |  |  |
--- | --- | --- | --- | --- | --- | ---
Sep. 30, 2021 USD ($) | Sep. 30, 2020 USD ($) | Sep. 30, 2021 USD ($) | Sep. 30, 2020 USD ($) | Nov. 30, 2020 USD ($) | Aug. 30, 2018 ft² | Apr. 30, 2018 USD ($) | Apr. 30, 2015 ft²
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |
Operating lease future minimum payments due | [1] | $ 9,916,000 |  | $ 9,916,000 |  |  |  |  |
Operating lease minimum future commitments |  | 7,925,000 |  | 7,925,000 |  |  |  |  |
PNAI [Member] |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |
Operating lease minimum future commitments |  |  |  |  |  | $ 9,916,000 |  |  |
Operating lease, rent expense |  | 0 | $ 535,000 | 0 | $ 1,605,000 |  |  |  |
PNAI [Member] | Research And Laboratory Equipment [Member] |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |
Operating lease, rent expense |  | 0 |  | 0 | $ 256,000 |  |  |  |
PNAI [Member] | Office and Laboratory Space at Woborn Massauchets [Member] |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |
Area of real estate availed on lease | ft² |  |  |  |  |  |  | 24,606 |  | 3,800
Operating lease term |  |  |  |  |  |  | 84 months |  | 39 months
Operating lease renewal term |  |  |  |  |  |  | 3 years |  |
Letters of credit outstanding |  |  |  |  |  |  |  | $ 293,000 |
Operating lease future minimum payments due |  | $ 9,916,000 |  | $ 9,916,000 |  |  |  |  |
Operating lease minimum future commitments |  |  |  |  |  | $ 7,925,000 |  |  |
[1] | Future minimum lease payments include repayment of outstanding restructuring liabilities.

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