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Commitments and Contingencies - Additional Information (Detail)		3 Months Ended		9 Months Ended
		Sep. 30, 2021 USD ($)	Sep. 30, 2020 USD ($)	Sep. 30, 2021 USD ($)	Sep. 30, 2020 USD ($)	Nov. 30, 2020 USD ($)	Aug. 30, 2018 ft²	Apr. 30, 2018 USD ($)	Apr. 30, 2015 ft²
Other Commitments [Line Items]
Operating lease future minimum payments due	[1]	$ 9,916,000		$ 9,916,000
Operating lease minimum future commitments		7,925,000		7,925,000
PNAI [Member]
Other Commitments [Line Items]
Operating lease minimum future commitments						$ 9,916,000
Operating lease, rent expense		0	$ 535,000	0	$ 1,605,000
PNAI [Member] | Research And Laboratory Equipment [Member]
Other Commitments [Line Items]
Operating lease, rent expense		0		0	$ 256,000
PNAI [Member] | Office and Laboratory Space at Woborn Massauchets [Member]
Other Commitments [Line Items]
Area of real estate availed on lease | ft²							24,606		3,800
Operating lease term							84 months		39 months
Operating lease renewal term							3 years
Letters of credit outstanding								$ 293,000
Operating lease future minimum payments due		$ 9,916,000		$ 9,916,000
Operating lease minimum future commitments						$ 7,925,000
[1] Future minimum lease payments include repayment of outstanding restructuring liabilities.

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Area of a real estate property.

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Term of lessee's operating lease renewal, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

+ References

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-Publisher FASB
-Name Accounting Standards Codification
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