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Segment Reporting - Schedule of Segment Operating Expenses Including Segment Expenses, and Net Loss (Detail) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2024 | Dec. 31, 2023
Operating expenses: |  |  |
Direct research and development |  | $ 126,172 | $ 78,225
Total operating expenses |  | 167,170 | 102,012
Loss from operations |  | (167,170) | (102,012)
Other income (expense): |  |  |
Interest income |  | 20,714 | 7,979
Interest expense |  | (7,626) | (3,786)
Loss before provision for income taxes |  | (152,147) | (95,989)
Provision for income taxes |  | 1 | 1
Segment and consolidated net loss |  | 152,148 | 95,990
Operating Segments [Member] |  |  |
Operating expenses: |  |  |
Payroll and related |  | 48,843 | 28,878
Depreciation and amortization |  | 105 | 22
Other segment items* | [1] | 35,190 | 18,452
Total operating expenses |  | 167,170 | 102,012
Loss from operations |  | (167,170) | (102,012)
Other income (expense): |  |  |
Interest income |  | 20,714 | 7,979
Interest expense |  | (7,626) | (3,786)
Other segment items** | [2] | 1,935 | 1,830
Loss before provision for income taxes |  | (152,147) | (95,989)
Provision for income taxes |  | (1) | (1)
Segment and consolidated net loss |  | (152,148) | (95,990)
Other Significant Items: |  |  |
Expenditures for additions to long-lived assets |  | (972) | (63)
Operating Segments [Member] | Clinical Trials [Member] |  |  |
Operating expenses: |  |  |
Direct research and development |  | 32,279 | 19,611
Operating Segments [Member] | Contract Manufacturing [Member] |  |  |
Operating expenses: |  |  |
Direct research and development |  | $ 50,753 | $ 35,049
[1] | *Other segment items included in total operating expenses primarily consist of consulting and contractors, professional services, equipment and software, travel and entertainment, facilities, medical affairs, commercial planning, and corporate communications.
[2] | **Other segment items included in loss before provision for income taxes consist of currency exchange gains and losses and other income/expense.

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