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Net loss per share - Antidilutive Securities (Details) - shares
9 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Total potentially dilutive securities (in shares) 21,077,679 16,610,721
Stock options outstanding    
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Total potentially dilutive securities (in shares) 4,583,520 5,707,634
Unvested restricted stock units    
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Total potentially dilutive securities (in shares) 8,821,852 3,427,190
Shares related to the 2026 Notes    
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Total potentially dilutive securities (in shares) 7,475,897 7,475,897
Shares committed under the 2021 ESPP    
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Total potentially dilutive securities (in shares) 196,410 0