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Income Taxes (Details 3) (USD $)
 12 Months Ended 24 Months Ended
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2013
Oct. 02, 2013
Synos
Income Taxes          
Income tax provision (benefit) at U.S. statutory rates $ (24,923,000) $ 13,366,000 $ 95,231,000    
State income tax expense (benefit), (net of federal impact) (1,554,000) (89,000) 1,616,000    
Nondeductible expenses 195,000 622,000 (749,000)    
Domestic production activities deduction 1,554,000 (489,000) (4,581,000)    
Nondeductible compensation 11,000 205,000 841,000    
Research and development tax credit (3,151,000) (3,013,000) (4,675,000)    
Net change in valuation allowance 2,420,000 2,943,000 121,000    
Change in accrual for unrecognized tax benefits 577,000 533,000 824,000    
Foreign tax rate differential (4,275,000) (2,387,000) (5,225,000)    
Other 199,000 (34,000) (1,819,000)    
Total provision (benefit) for income taxes (28,947,000) 11,657,000 81,584,000    
Research and development tax credit attributable to 2012 1,900,000        
Additional tax of foreign jurisdiction 900,000 4,000,000   4,900,000  
Excess tax benefits from stock option exercises   2,119,000 10,406,000    
Increase in additional paid in capital upon realization of research and development credits 500,000        
Income taxes          
Percentage of total outstanding stock acquired         100.00%
Deferred tax liability related to acquisition         $ 32,400,000