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v3.20.4

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Cash flow from operating activities |  |  |
Net loss | $ (122,858) | $ (84,710) | $ (49,594)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Stock-based compensation expense | 21,825 | 8,981 | 3,874
Depreciation and amortization | 3,149 | 3,578 | 3,664
Amortization of right-of-use assets | 1,042 |  |
Share of loss (gain on deemed sale) from equity method investee, net |  | 1,202 | (343)
Amortization of premiums on investments | (46) | (2,638) | (1,752)
Other non-operating income |  |  | (177)
Changes in operating assets and liabilities: |  |  |
Receivable from collaboration partners (($943), $0 and $0 from a related party) | (917) | (132) |
Amounts owed by PACT Pharma |  | 83 | (58)
Prepaid expenses and other current assets | (838) | (1,982) | (1,180)
Other long-term assets | (5,374) | (588) | (80)
Accounts payable | 9,272 | 1,726 | (69)
Accrued research and development expenses | 13,735 | 1,756 | 1,623
Other accrued liabilities | 4,593 | 1,743 | 1,874
Other current liabilities |  | 57 | 43
Deferred revenue ($185,379, $0 and $0 to a related party) | 178,379 | (2,000) | (353)
Operating lease liabilities | (993) |  |
Deferred rent |  | (538) | (468)
Other long-term liabilities ($9,703, $0 and $0 to a related party) | 10,201 |  |
Net cash provided by (used in) operating activities | 111,170 | (73,462) | (42,996)
Cash flow from investing activities |  |  |
Purchases of short-term and long-term investments | (739,658) | (247,755) | (261,552)
Proceeds from maturities of short-term and long-term investments | 307,343 | 308,892 | 151,855
Sales of short-term investments | 1,003 |  |
Purchases of property and equipment | (3,055) | (1,925) | (3,743)
Net cash provided by (used in) investing activities | (434,367) | 59,212 | (113,440)
Cash flow from financing activities |  |  |
Proceeds from initial public offering, net of issuance costs |  |  | 125,111
Proceeds from issuance of common stock and rights to purchase additional shares ($164,207, $0 and $0 from a related party) | 433,776 |  |
Proceeds from issuance of common stock pursuant to equity award plans | 4,953 | 1,217 | 4,098
Repurchase of unvested shares of stock | (54) | (94) |
Payment of preferred stock issuance costs |  |  | (135)
Net cash provided by financing activities | 438,675 | 1,123 | 129,074
Net increase (decrease) in cash, cash equivalents and restricted cash | 115,478 | (13,127) | (27,362)
Cash, cash equivalents and restricted cash at beginning of period | 58,140 | 71,267 | 98,629
Cash, cash equivalents and restricted cash at end of period | 173,618 | 58,140 | 71,267
Supplemental disclosures: |  |  |
Cash paid for amounts included in measurement of lease liabilities | 2,105 |  |
Non-cash investing and financing activities: |  |  |
Right-of-use assets obtained in exchange for new operating lease liabilities | 8,019 |  |
Unpaid portion of financing costs included in accounts payable | 61 |  |
Unpaid portion of property and equipment purchases included in accounts payable and accrued liabilities | 1,583 | 12 | 136
Vesting of early exercised stock options and restricted stock | $ 848 | $ 1,029 | $ 1,276

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