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Net Loss per Share (Tables) | 3 Months Ended
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Mar. 31, 2022
Earnings Per Share [Abstract] |
Computation of Basic and Diluted Net Loss Per Share | The following table sets forth the computation of basic and diluted net loss per share (in thousands, except share and per share data):
|  | Three Months Ended March 31, |
|  | 2022 |  |  | 2021 |
Numerator: |  |  |  |  |  |
Net loss |  | $ | (67,993 | ) |  | $ | (72,593 | )
Denominator: |  |  |  |  |  |
Weighted-average common shares outstanding |  |  | 71,194,778 |  |  |  | 68,476,799 |
Less: weighted-average common shares subject to vesting |  |  | - |  |  |  | (1,394,638 | )
Weighted-average common shares used to compute basic and diluted net loss per share |  |  | 71,194,778 |  |  |  | 67,082,161 |
Net loss per share: basic and diluted |  | $ | (0.96 | ) |  | $ | (1.08 | )
Summary of Outstanding Potentially Dilutive Securities Excluded from Computation of Diluted Net Loss per Share | The following outstanding potentially dilutive securities were excluded from the computation of diluted net loss per share because including them would have been antidilutive:
|  | Three Months Ended March 31, |
|  | 2022 |  |  | 2021 |
Common stock options issued and outstanding |  |  | 12,564,969 |  |  |  | 11,708,625 |
Restricted stock units issued |  |  | 1,558,381 |  |  |  | 1,532,162 |
Employee Stock Purchase Plan shares |  |  | 102,414 |  |  |  | 96,591 |
Unvested early exercised common stock options |  |  | - |  |  |  | 111,094 |
Unvested restricted common stock issued as part of collaboration agreement |  |  | - |  |  |  | 1,257,651 |
Total |  |  | 14,225,764 |  |  |  | 14,706,123 |

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- Definition Tabular disclosure of securities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) in the future that were not included in the computation of diluted EPS because to do so would increase EPS amounts or decrease loss per share amounts for the period presented, by antidilutive securities. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 260 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=124432515&loc=d3e3550-109257 + Details
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- Definition Tabular disclosure of an entity's basic and diluted earnings per share calculations, including a reconciliation of numerators and denominators of the basic and diluted per-share computations for income from continuing operations. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 260 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=124432515&loc=d3e3550-109257 + Details
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