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Business Segment | 3 Months Ended
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Mar. 31, 2026
Segment Reporting [Abstract] |
Business Segment | Business segment We operate and manage our business as one reportable and operating segment, which is the business of developing and commercializing highly differentiated therapies that have a meaningful impact on patients. Our chief operating decision maker ("CODM") is the Chief Executive Officer, who decides how to allocate resources and assesses segment performance based on the net loss reported in the Condensed Consolidated Statements of Operations. The table below is a summary of the segment net loss, including significant segment expenses (in millions):
|  |  | Three Months Ended March 31,
|  |  |  |  |  |  | 2026 |  | 2025
Total revenues |  |  |  |  |  |  | 17 |  |  | 28 |
Adjusted for expense (income): |  |  |  |  |  |  |  |  |
Late-stage development programs (1) |  |  |  |  |  |  | 60 |  |  | 55 |
Early-stage development and preclinical programs (2) |  |  |  |  |  |  | 18 |  |  | 42 |
Compensation and personnel costs |  |  |  |  |  |  | 70 |  |  | 66 |
Depreciation and amortization |  |  |  |  |  |  | 2 |  |  | 3 |
Interest income, net |  |  |  |  |  |  | (6) |  |  | (10) |
Other segment items (3) |  |  |  |  |  |  | 20 |  |  | 22 |
Partnership reimbursements |  |  |  |  |  |  | (19) |  |  | (38) |
Segment net loss and Consolidated net loss |  |  |  |  |  |  | $ | (128) |  |  | $ | (112) |
(1) R&D expenses incurred related to a Phase 3 clinical program intended to result in registration of a new product. This includes all unallocated program-level expense not directly attributable to a specific clinical trial once the related program enters into one or more Phase 3 clinical trials. (2) R&D expenses incurred for activities ranging from early-stage development and preclinical to Phase 2 clinical trials. This includes all unallocated program-level expense not directly attributable to a specific clinical trial unless the related program has entered into one or more Phase 3 clinical trials. (3) Other segment items includes non-allocated program costs and other G&A costs. Total segment assets at March 31, 2026 and 2025 were $1.0 billion and $1.2 billion, respectively.

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- Definition The entire disclosure for reporting segments including data and tables. Reportable segments include those that meet any of the following quantitative thresholds a) it's reported revenue, including sales to external customers and intersegment sales or transfers is 10 percent or more of the combined revenue, internal and external, of all operating segments b) the absolute amount of its reported profit or loss is 10 percent or more of the greater, in absolute amount of 1) the combined reported profit of all operating segments that did not report a loss or 2) the combined reported loss of all operating segments that did report a loss c) its assets are 10 percent or more of the combined assets of all operating segments. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 21 -Subparagraph (b) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-21 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name 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