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Stockholders' Equity (Tables) | 9 Months Ended
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Sep. 30, 2023
Equity [Abstract] |
Summary of Changes in Stockholders' Equity | The following table presents the changes in stockholders’ equity for the three and nine months ended September 30, 2023:
(In thousands, except share data) |  | Common Stock $0.0001 Par Value |  |  | Additional Paid-In Capital |  |  | Accumulated Other Comprehensive (Loss)/Income |  |  | Accumulated Deficit |  |  | Total Stockholders’ Equity |
|  | Shares |  |  | Amount |  |  |  |  |  |  |  |  |  |  |  |  |
Balance as of December 31, 2022 |  |  | 68,111,385 |  |  | $ | 7 |  |  | $ | 1,161,288 |  |  | $ | (806 | ) |  | $ | (693,040 | ) |  | $ | 467,449 |
Stock purchase under ESPP |  |  | 16,537 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Stock-based compensation expense |  |  | — |  |  |  | — |  |  |  | 6,238 |  |  |  | — |  |  |  | — |  |  |  | 6,238 |
Unrealized gains on investments |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 470 |  |  |  | — |  |  |  | 470 |
Vesting of RSU |  |  | 5,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Employee withholdings ESPP |  |  | — |  |  |  | — |  |  |  | 196 |  |  |  | — |  |  |  | — |  |  |  | 196 |
Prefunded warrants, exercise |  |  | 85,998 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Proceeds from exercise of stock options |  |  | 276,506 |  |  |  | — |  |  |  | 2,278 |  |  |  | — |  |  |  | — |  |  |  | 2,278 |
Net loss |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (41,126 | ) |  |  | (41,126 | )
Balance as of March 31, 2023 |  |  | 68,495,426 |  |  | $ | 7 |  |  | $ | 1,170,000 |  |  | $ | (336 | ) |  | $ | (734,166 | ) |  | $ | 435,505 |
Stock-based compensation expense |  |  | — |  |  |  | — |  |  |  | 8,065 |  |  |  | — |  |  |  | — |  |  |  | 8,065 |
Unrealized loss on investments |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (238 | ) |  |  | — |  |  |  | (238 | )
Vesting of RSU |  |  | 1,602 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Employee withholdings ESPP |  |  | — |  |  |  | — |  |  |  | 179 |  |  |  | — |  |  |  | — |  |  |  | 179 |
Prefunded warrants, exercise |  |  | 771,133 |  |  |  | — |  |  |  | (1 | ) |  |  | — |  |  |  | — |  |  |  | (1 | )
Proceeds from exercise of stock options |  |  | 163,037 |  |  |  | — |  |  |  | 1,146 |  |  |  | — |  |  |  | — |  |  |  | 1,146 |
Net loss |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (44,615 | ) |  |  | (44,615 | )
Balance as of June 30, 2023 |  |  | 69,431,198 |  |  | $ | 7 |  |  | $ | 1,179,389 |  |  | $ | (574 | ) |  | $ | (778,781 | ) |  | $ | 400,041 |
Stock-based compensation expense |  |  | — |  |  |  | — |  |  |  | 8,321 |  |  |  | — |  |  |  | — |  |  |  | 8,321 |
Unrealized gains on investments |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 119 |  |  |  | — |  |  |  | 119 |
Stock purchase under ESPP |  |  | 18,260 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Employee withholdings ESPP |  |  | — |  |  |  | — |  |  |  | 259 |  |  |  | — |  |  |  | — |  |  |  | 259 |
Prefunded warrants, exercise |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Proceeds from exercise of stock options |  |  | 188,710 |  |  |  | — |  |  |  | 1,592 |  |  |  | — |  |  |  | — |  |  |  | 1,592 |
Net loss |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (51,146 | ) |  |  | (51,146 | )
Balance as of September 30, 2023 |  |  | 69,638,168 |  |  | $ | 7 |  |  | $ | 1,189,561 |  |  | $ | (455 | ) |  | $ | (829,927 | ) |  | $ | 359,186 |
The following table presents the changes in stockholders’ equity for the three and nine months ended September 30, 2022:
(In thousands, except share data) |  | Common Stock $0.0001 Par Value |  |  | Additional Paid-In Capital |  |  | Accumulated Other Comprehensive (Loss)/Income |  |  | Accumulated Deficit |  |  | Total Stockholders’ Equity |
|  | Shares |  |  | Amount |  |  |  |  |  |  |  |  |  |  |  |  |
Balance as of December 31, 2021 |  |  | 54,983,105 |  |  | $ | 6 |  |  | $ | 952,019 |  |  | $ | 45 |  |  | $ | (543,702 | ) |  | $ | 408,368 |
Stock purchase under ESPP |  |  | 18,946 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Stock-based compensation expense |  |  | — |  |  |  | — |  |  |  | 3,478 |  |  |  | — |  |  |  | — |  |  |  | 3,478 |
Unrealized loss on short-term investments |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (685 | ) |  |  | — |  |  |  | (685 | )
Employee withholdings ESPP |  |  | — |  |  |  | — |  |  |  | 92 |  |  |  | — |  |  |  | — |  |  |  | 92 |
Proceeds from exercise of stock options |  |  | 28,839 |  |  |  | — |  |  |  | 465 |  |  |  | — |  |  |  | — |  |  |  | 465 |
Net loss |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (37,169 | ) |  |  | (37,169 | )
Balance as of March 31, 2022 |  |  | 55,030,890 |  |  | $ | 6 |  |  | $ | 956,054 |  |  | $ | (640 | ) |  | $ | (580,871 | ) |  | $ | 374,549 |
Proceeds from ATM sales |  |  | 1,111,111 |  |  |  | — |  |  |  | 19,427 |  |  |  | — |  |  |  | — |  |  |  | 19,427 |
Stock-based compensation expense |  |  | — |  |  |  | — |  |  |  | 3,938 |  |  |  | — |  |  |  | — |  |  |  | 3,938 |
Unrealized loss on short-term investments |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (695 | ) |  |  | — |  |  |  | (695 | )
Employee withholdings ESPP |  |  | — |  |  |  | — |  |  |  | 58 |  |  |  | — |  |  |  | — |  |  |  | 58 |
Proceeds from exercise of stock options |  |  | 257,733 |  |  |  | — |  |  |  | 2,235 |  |  |  | — |  |  |  | — |  |  |  | 2,235 |
Net loss |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (37,572 | ) |  |  | (37,572 | )
Balance as of June 30, 2022 |  |  | 56,399,734 |  |  | $ | 6 |  |  | $ | 981,712 |  |  | $ | (1,335 | ) |  | $ | (618,443 | ) |  | $ | 361,940 |
Stock purchase under ESPP |  |  | 10,053 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Stock-based compensation expense |  |  | — |  |  |  | — |  |  |  | 4,362 |  |  |  | — |  |  |  | — |  |  |  | 4,362 |
Unrealized loss on short-term investments |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (270 | ) |  |  | — |  |  |  | (270 | )
Exercise of prefunded warrants |  |  | 2,832,151 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Employee withholdings ESPP |  |  | — |  |  |  | — |  |  |  | 110 |  |  |  | — |  |  |  | — |  |  |  | 110 |
Proceeds from exercise of stock options |  |  | 880,723 |  |  |  | — |  |  |  | 7,363 |  |  |  | — |  |  |  | — |  |  |  | 7,363 |
Net loss |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (35,403 | ) |  |  | (35,403 | )
Balance as of September 30, 2022 |  |  | 60,122,661 |  |  | $ | 6 |  |  | $ | 993,547 |  |  | $ | (1,605 | ) |  | $ | (653,846 | ) |  | $ | 338,102 |
Schedule of Common Stock Reserved for Future Issuance | The Company has reserved for future issuance the following shares of common stock related to the potential warrant exercise, exercise of stock options and the employee stock purchase plan:
| September 30, 2023 |
Common stock issuable under pre-funded warrants |  | 285,714 |
Options to purchase common stock |  | 13,543,965 |
Employee Stock Purchase Plan |  | 1,732,614 |

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- Definition Tabular disclosure of changes in the separate accounts comprising stockholders' equity (in addition to retained earnings) and of the changes in the number of shares of equity securities during at least the most recent annual fiscal period and any subsequent interim period presented is required to make the financial statements sufficiently informative if both financial position and results of operations are presented. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -SubTopic 10 -Topic 505 -Publisher FASB -URI https://asc.fasb.org//1943274/2147481112/505-10-50-2 + Details
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