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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2023
Sep. 30, 2022
CASH FLOWS FROM OPERATING ACTIVITIES:    
Net loss $ (136,887) $ (110,144)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation 9 30
Accretion of investments (11,344) (1,357)
Non-cash operating lease expense 496 309
Non-cash interest expense 0 1,103
Changes in fair value of derivative liability 0 (187)
Stock-based compensation 22,624 11,778
Changes in operating assets and liabilities:    
Prepaid expenses and other assets (3,281) (7,674)
Collaboration receivable (payable), net 68 (4,539)
Accounts payable 1,699 1,445
Accrued expenses and other liabilities 7,364 (1,545)
Net cash used in operating activities (119,252) (110,781)
CASH FLOWS FROM INVESTING ACTIVITIES:    
Purchases of short and long-term investments (225,316) (244,467)
Proceeds from sales of equipment 0 225
Proceeds from sales and maturities of short-term investments 359,215 195,683
Proceeds from Sale of Machinery and Equipment 0 225
Net cash provided by (used in) investing activities 133,899 (48,559)
CASH FLOWS FROM FINANCING ACTIVITIES:    
Proceeds from Employee Stock Purchase Plan 633 260
Proceeds from stock option exercises 5,016 10,063
Proceeds from issuance of common stock in at-the-market stock offering, net 0 19,427
Payment on term loan 0 (20,998)
Net cash provided by financing activities 5,649 8,752
NET INCREASE (DECREASE) IN CASH, CASH EQUIVALENTS AND RESTRICTED CASH 20,296 (150,588)
CASH, CASH EQUIVALENTS AND RESTRICTED CASH—beginning of period 74,471 222,080
CASH, CASH EQUIVALENTS AND RESTRICTED CASH —end of period 94,767 71,492
SUPPLEMENTAL DISCLOSURE OF CASH FLOW INFORMATION:    
Cash paid for interest $ 0 $ 2,059