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Common Stock - Additional Information (Detail) - USD ($)
$ / shares in Units, $ in Thousands
 1 Months Ended 12 Months Ended
May 26, 2023
Jan. 24, 2023
Dec. 31, 2023
May 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Mar. 31, 2021
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
May 09, 2023
Apr. 12, 2023
Mar. 08, 2016
Class Of Stock [Line Items]                          
Common stock, shares authorized     200,000,000   100,000,000     200,000,000 100,000,000        
Proceeds from issuance of common stock in follow-on public stock offering, net           $ 81,200              
Common stock, new shares issued   86,000 12,432,431   7,840,909 3,802,144              
Common Stock, Capital Shares Reserved for Future Issuance     23,906,260         23,906,260          
Number Of Pre Funded Warrants Exercised For Common Stock   85,998                 498,137 272,996  
Offering price     $ 18.5   $ 22                
Gross proceeds from offering     $ 230,000   $ 172,500                
Common stock, par value     $ 0.0001   $ 0.0001     $ 0.0001 $ 0.0001        
Common stock issued at fair value                   $ 24,848      
Incyte Collaboration Agreement and Share Purchase Agreement [Member]                          
Class Of Stock [Line Items]                          
Proceeds from issuance of common stock in follow-on public stock offering, net           $ 35,000              
Common stock, new shares issued           1,421,523              
Common stock issued at fair value           $ 24,800   $ 14,000 $ 10,500        
Pre-Funded Warrants [Member]                          
Class Of Stock [Line Items]                          
Common Stock, Capital Shares Reserved for Future Issuance     285,714         285,714       273,000  
Number Of Pre Funded Warrants Exercised For Common Stock                     498,142    
Warrants issued (in shares)           1,142,856       1,142,856      
Offering price           $ 17.4999              
Common Stock [Member]                          
Class Of Stock [Line Items]                          
Common stock, new shares issued                   1,421,523      
Series Warrants [Member]                          
Class Of Stock [Line Items]                          
Offering price           $ 17.5              
At The Market Equity Offering Sales Agreement [Member]                          
Class Of Stock [Line Items]                          
Proceeds from issuance of common stock in follow-on public stock offering, net $ 25,000             $ 42,100          
Common stock, new shares issued               2,719,744          
Cowen and Company LLC [Member] | At The Market Equity Offering Sales Agreement [Member]                          
Class Of Stock [Line Items]                          
Proceeds from issuance of common stock in follow-on public stock offering, net       $ 200,000     $ 75,000            
Initial Public Offering [Member]                          
Class Of Stock [Line Items]                          
Common stock, shares authorized                         200,000,000