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Consolidated Statements of Stockholders' Equity - USD ($)
$ in Thousands
Total
Direct Placement Offering [Member]
Common Stock [Member]
Common Stock [Member]
Direct Placement Offering [Member]
Additional Paid-In Capital [Member]
Additional Paid-In Capital [Member]
Direct Placement Offering [Member]
Accumulated Other Comprehensive Income (Loss) [Member]
Accumulated Deficit [Member]
Beginning balance at Dec. 31, 2020 $ 252,188   $ 5   $ 820,815   $ (4) $ (568,628)
Beginning balance, Shares at Dec. 31, 2020     47,881,223          
Proceeds from "at-the-market" offering, net, Value 5,131       5,131      
Proceeds from "at-the-market" offering, net, Shares     277,629          
Proceeds from direct offering, net, value   $ 81,206   $ 1   $ 81,205    
Proceeds from direct offering,net, Shares       3,802,144        
Stock purchase under ESPP, Shares     26,878          
Pre-funded warrant cashless exercise, shares     725,784          
Proceeds from Incyte Share Purchase Agreement 24,848       24,848      
Proceeds from Incyte Share Purchase Agreement shares     1,421,523          
Stock-based compensation expense 13,317       13,317      
Unrealized (gain) loss on investments 49           49  
Vesting of RSU, Shares     5,500          
Employee withholdings ESPP 367       367      
Proceeds from exercise of stock options $ 6,336       6,336      
Proceeds from exercise of stock options, Shares 842,424   842,424          
Net Income (Loss) $ 24,926             24,926
Ending balance at Dec. 31, 2021 408,368   $ 6   952,019   45 (543,702)
Ending balance, Shares at Dec. 31, 2021     54,983,105          
Proceeds from "at-the-market" offering, net, Value 19,425       19,425      
Proceeds from "at-the-market" offering, net, Shares     1,111,111          
Proceeds from direct offering, net, value   161,966   $ 1   161,965    
Proceeds from direct offering,net, Shares       7,840,909        
Stock purchase under ESPP, Shares     28,999          
Pre-funded warrant cashless exercise, shares     2,832,151          
Stock-based compensation expense 16,019       16,019      
Unrealized (gain) loss on investments (851)           (851)  
Vesting of RSU, Shares     38,749          
Employee withholdings ESPP 401       401      
Proceeds from exercise of stock options $ 11,459       11,459      
Proceeds from exercise of stock options, Shares 1,300,000   1,276,361          
Net Income (Loss) $ (149,338)             (149,338)
Ending balance at Dec. 31, 2022 467,449   $ 7   1,161,288   (806) (693,040)
Ending balance, Shares at Dec. 31, 2022     68,111,385          
Proceeds from "at-the-market" offering, net, Value 42,139       42,139      
Proceeds from "at-the-market" offering, net, Shares     2,719,744          
Proceeds from direct offering, net, value   $ 215,955   $ 1   $ 215,954    
Proceeds from direct offering,net, Shares       12,432,431        
Stock purchase under ESPP, Shares     34,797          
Pre-funded warrant cashless exercise, shares     857,131          
Stock-based compensation expense 30,951       30,951      
Unrealized (gain) loss on investments 1,024           1,024  
Vesting of RSU, Shares     9,102          
Employee withholdings ESPP 910       910      
Proceeds from exercise of stock options $ 5,128       5,128      
Proceeds from exercise of stock options, Shares 662,042   662,042          
Net Income (Loss) $ (209,360)             (209,360)
Ending balance at Dec. 31, 2023 $ 554,196   $ 8   $ 1,456,370   $ 218 $ (902,400)
Ending balance, Shares at Dec. 31, 2023     84,826,632