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Segment Reporting | 6 Months Ended
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Jun. 30, 2026
Segment Reporting [Abstract] |
Segment Reporting | 17. Segment Reporting The Company manages its business activities on a consolidated basis and operate as a single operating and reportable segment: Syndax Pharmaceuticals. The Company primarily derives revenue in the United States through milestone revenue and product sales on the approved products, Revuforj® (revumenib) and Niktimvo™ (axatilimab-csfr). The accounting policies of the segment are the same as those described in Note 3 – Summary of Significant Accounting Policies. To assess performance, the Company’s Chief Operating Decision Maker, or CODM, Michael Metzger, uses consolidated net loss as the segment’s measure of segment profit or loss. The CODM uses net loss in the budget and forecasting process and considers budget-to actual variances on a quarterly basis when making decisions about the allocation of operating and capital resources. The following table provides the operating financial results of our biopharmaceutical cancer therapeutics segment:
|  | Three Months Ended June 30, |  |  | Six Months Ended June 30, |
|  | 2026 |  |  | 2025 |  |  | 2026 |  |  | 2025 |
June 30, 2026 |  |  |  |  |  |  |  |  |  |  |  |
Total Revenue |  | $ | 72,788 |  |  | $ | 37,958 |  |  | $ | 137,652 |  |  | $ | 57,753 |
Less: Significant and other segment expenses |  |  |  |  |  |  |  |  |  |  |  |
Cost of product sales |  |  | 3,208 |  |  |  | 1,279 |  |  |  | 5,841 |  |  |  | 2,164 |
Research and development expenses |  |  |  |  |  |  |  |  |  |  |  |
Revumenib-related costs |  |  | 35,493 |  |  |  | 28,155 |  |  |  | 61,218 |  |  |  | 48,960 |
Axatilimab-related costs |  |  | 8,682 |  |  |  | 9,053 |  |  |  | 18,315 |  |  |  | 28,764 |
Other R&D programs |  |  | 1,043 |  |  |  | 1,826 |  |  |  | 1,205 |  |  |  | 2,747 |
Personnel cost and other expenses |  |  | 18,308 |  |  |  | 18,997 |  |  |  | 37,606 |  |  |  | 35,528 |
General and administrative expenses |  |  |  |  |  |  |  |  |  |  |  |
Commercial-related expenses |  |  | 9,869 |  |  |  | 9,914 |  |  |  | 17,590 |  |  |  | 20,739 |
Personnel cost and other expenses |  |  | 16,298 |  |  |  | 19,307 |  |  |  | 32,999 |  |  |  | 38,389 |
Other SG&A expenses |  |  | 5,868 |  |  |  | 4,993 |  |  |  | 11,008 |  |  |  | 9,405 |
Stock-based compensation |  |  | 14,014 |  |  |  | 13,787 |  |  |  | 26,067 |  |  |  | 24,167 |
Royalty interest expense |  |  | 12,119 |  |  |  | 7,854 |  |  |  | 23,965 |  |  |  | 15,903 |
Convertible note interest expense |  |  | 555 |  |  |  | — |  |  |  | 555 |  |  |  | — |
Interest expense (income), net |  |  | (3,744 | ) |  |  | (5,946 | ) |  |  | (7,305 | ) |  |  | (13,127 | )
Other expense, net |  |  | 438 |  |  |  | 586 |  |  |  | 624 |  |  |  | 807 |
Segment net loss |  | $ | (49,363 | ) |  | $ | (71,847 | ) |  | $ | (92,036 | ) |  | $ | (156,693 | )

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