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v3.26.1

Segment Reporting - Schdule of Operating Financial Result (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2026 | Mar. 31, 2026 | Jun. 30, 2025 | Mar. 31, 2025 | Jun. 30, 2026 | Jun. 30, 2025
Segment Reporting [Line Items] |  |  |  |  |  |
Total Revenue | $ 72,788 |  | $ 37,958 |  | $ 137,652 | $ 57,753
Less: Significant and other segment expenses |  |  |  |  |  |
Cost of Product Sales | 3,208 |  | 1,279 |  | 5,841 | 2,164
Research and development | 68,036 |  | 62,227 |  | 126,881 | 123,863
Royalty interest expense | 12,119 |  | 7,854 |  | 23,965 | 15,903
Convertible note interest expense | 555 |  | 0 |  | 555 | 0
Segment net loss | (49,363) | $ (42,673) | (71,847) | $ (84,846) | (92,036) | (156,693)
Biopharmaceutical Cancer Therapeutics Member |  |  |  |  |  |
Segment Reporting [Line Items] |  |  |  |  |  |
Total Revenue | 72,788 |  | 37,958 |  | 137,652 | 57,753
Less: Significant and other segment expenses |  |  |  |  |  |
Cost of Product Sales | 3,208 |  | 1,279 |  | 5,841 | 2,164
Other R&D programs | 1,043 |  | 1,826 |  | 1,205 | 2,747
Personnel cost and other expenses | 18,308 |  | 18,997 |  | 37,606 | 35,528
Commercial related expenses | 9,869 |  | 9,914 |  | 17,590 | 20,739
Personnel cost and other expenses | 16,298 |  | 19,307 |  | 32,999 | 38,389
Other SG&A expenses | 5,868 |  | 4,993 |  | 11,008 | 9,405
Stock-based compensation | 14,014 |  | 13,787 |  | 26,067 | 24,167
Royalty interest expense | 12,119 |  | 7,854 |  | 23,965 | 15,903
Convertible note interest expense | 555 |  | 0 |  | 555 | 0
Interest expense (income), net | (3,744) |  | (5,946) |  | (7,305) | (13,127)
Other expense, net | 438 |  | 586 |  | 624 | 807
Segment net loss | (49,363) |  | (71,847) |  | (92,036) | (156,693)
Biopharmaceutical Cancer Therapeutics Member | Revumenib-Related Costs Member |  |  |  |  |  |
Less: Significant and other segment expenses |  |  |  |  |  |
Research and development | 35,493 |  | 28,155 |  | 61,218 | 48,960
Biopharmaceutical Cancer Therapeutics Member | Axatilimab-Related Costs Member |  |  |  |  |  |
Less: Significant and other segment expenses |  |  |  |  |  |
Research and development | $ 8,682 |  | $ 9,053 |  | $ 18,315 | $ 28,764

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