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Income Taxes - Schedule of Effective Income Tax Rate Reconciliation (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Income Tax Disclosure [Abstract]
U.S. federal tax provision at statutory rate	$ (308)	$ (682)	$ 16,181
State taxes	19	(311)	1,365
Non-deductible expenses	1,373	1,212	551
Acquisition costs	0	845	239
Share-based compensation expense	39	1,941	748
Research tax credits	(3,233)	(2,075)	(1,324)
Domestic production deduction	(621)	(890)	(1,133)
Gain on investment	0	0	(1,205)
Tax audit settlement	0	(2,499)	0
Foreign rate differential	938	(154)	123
Stock option tax benefit	(5,926)	0	0
One-time Impact of the Tax Act	(13,391)	0	0
Other	(374)	62	(61)
Total provision for (benefit from) income taxes	$ (21,484)	$ (2,551)	$ 15,484

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