Three months ended								12-months ended
		31-Dec				31-Dec				31-Dec				31-Dec
		2004				2003				2004				2003
Revenues
Product sales			2207				3701				6397				10209
Contract research
and development			-161				284				1738				1301
Milestone and
licensing fees			0				62				125				275
Total revenues			2046				4047				8260				11785
Operating costs and
expenses:
Cost of sales			1362				674				3490				2057
Research and
development			1539				2347				7369				10058
Selling and
marketing			6327				1714				23588				7790
General and
administrative			2724				2373				8716				7934
Facility exit costs			0								723				0
Gain on redemption of debt			0								(11162	)			0
Total operating
expenses			11952				7108				32724				27839
Loss from operations			(9906	)			(3060	)			(24464	)			(16054	)
Interest expense, net			(451	)			(23	)			(1526	)			(1219	)
Other income			70				0				70				0
Net loss			(10287	)			(3082	)			(25920	)			(17273	)
Basic and diluted
loss per share			($0.26	)			($0.10	)			($0.70	)			($0.58	)
Basic and diluted
weighted average number
of common shares
outstanding			39,553,876				32,342,478				36,926,034				29,852,797
Selected Balance Sheet Data										December 31, 2004				December 31, 2003
Cash & cash equivalents ($)											17,876				27,633
Total current assets											23,937				32,062
Working capital											15,361				27,226
Total assets											77,993				84,159
Convertible notes											35,970				41,100
Total stockholders’ equity											33,281				35,944