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STATEMENTS OF OPERATIONS (USD $) In Thousands, except Per Share data, unless otherwise specified | 12 Months Ended
--- | ---
Dec. 31, 2011 | Dec. 31, 2010 | Dec. 31, 2009
Contract revenue | $ 14,688 | $ 343 | $ 325
Costs and expenses: |  |  |
Cost of contract revenue | 7,003 |  |
Research and development | 17,885 | 28,032 | 25,780
General and administrative | 11,379 | 10,805 | 11,928
Total costs and expenses | 36,267 | 38,837 | 37,708
Loss from operations before other income (expense) | (21,579) | (38,494) | (37,383)
Other income (expense): |  |  |
Interest income | 136 | 189 | 285
Interest expense | (9) | (9) | (786)
Other income | 26 | 485 |
Impairment of short-term investments |  |  | (1,338)
Realized gains on short-term investments |  |  | 848
Change in fair value of warrant liability | 2,474 | 1,671 | (1,972)
Loss from operations before income tax | (18,952) | (36,158) | (40,346)
Income tax expense (benefit) | 412 | (450) |
Net loss | $ (19,364) | $ (35,708) | $ (40,346)
Basic and diluted net loss per share: | $ (0.17) | $ (0.34) | $ (0.47)
Basic and diluted weighted average number of common shares outstanding | 113,610 | 104,768 | 85,555

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