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CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Revenue: |  |  |
Government contracts | $ 33,344 | $ 26,213 | $ 17,708
Research and development collaborations | 2,906 | 4,446 | 3,207
Total revenue | 36,250 | 30,659 | 20,915
Expenses: |  |  |
Research and development | 162,644 | 94,422 | 58,530
General and administrative | 30,842 | 19,928 | 14,819
Total expenses | 193,486 | 114,350 | 73,349
Loss from operations | (157,236) | (83,691) | (52,434)
Other income (expense): |  |  |
Investment income | 660 | 286 | 187
Interest expense | (241) | (157) | (160)
Other income (expense), net | (120) | 0 | 182
Realized gains on marketable securities | 0 | 615 | 0
Change in fair value of warrant liability | 0 | 0 | 267
Loss from operations before income tax expense | (156,937) | (82,947) | (51,958)
Income tax expense | 0 | 0 | 25
Net loss | $ (156,937) | $ (82,947) | $ (51,983)
Basic and diluted net loss per share (in dollars per share) | $ (0.6) | $ (0.37) | $ (0.31)
Basic and diluted weighted average number of common shares outstanding (in shares) | 262,248 | 225,848 | 169,658

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