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        <link:definition>108 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS</link:definition>

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        <link:definition>112 - Disclosure - Summary of Significant Accounting Policies</link:definition>

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        <link:definition>114 - Disclosure - Fair Value Measurements</link:definition>

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        <link:definition>123 - Disclosure - Income Taxes</link:definition>

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        <link:definition>124 - Disclosure - Commitments and Contingencies</link:definition>

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        <link:definition>125 - Disclosure - Related Party Transactions</link:definition>

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        <link:definition>127 - Disclosure - Quarterly Financial Information (Unaudited)</link:definition>

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        <link:definition>128 - Disclosure - Summary of Significant Accounting Policies (Policies)</link:definition>

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        <link:definition>129 - Disclosure - Summary of Significant Accounting Policies (Tables)</link:definition>

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        <link:usedOn>link:definitionLink</link:usedOn>

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        <link:definition>130 - Disclosure - Fair Value Measurements (Tables)</link:definition>

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        <link:definition>131 - Disclosure - Marketable Securities (Tables)</link:definition>

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        <link:definition>132 - Disclosure - Goodwill and Intangible Assets (Tables)</link:definition>

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        <link:definition>133 - Disclosure - Other Financial Information (Tables)</link:definition>

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        <link:definition>134 - Disclosure - Long-Term Debt (Tables)</link:definition>

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        <link:definition>135 - Disclosure - Stock-Based Compensation (Tables)</link:definition>

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        <link:definition>136 - Disclosure - Income Taxes (Tables)</link:definition>

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        <link:definition>137 - Disclosure - Commitments and Contingencies (Tables)</link:definition>

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        <link:definition>138 - Disclosure - Quarterly Financial Information (Unaudited) ( Tables)</link:definition>

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        <link:definition>139 - Disclosure - Summary of Significant Accounting Policies (Narrative) (Details)</link:definition>

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        <link:definition>140 - Disclosure - Summary of Significant Accounting Policies (Cash and Equivalents) (Details)</link:definition>

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        <link:definition>141 - Disclosure - Acquisition (Narrative) (Details)</link:definition>

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        <link:definition>143 - Disclosure - Fair Value Measurements (Fair value hierarchy for its financial assets and liabilities) (Details)</link:definition>

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        <link:definition>144 - Disclosure - Marketable Securities (Narrative) (Details)</link:definition>

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        <link:definition>145 - Disclosure - Marketable Securities (Marketable securities classified as available-for-sale) (Details)</link:definition>

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        <link:definition>146 - Disclosure - Goodwill and Intangible Assets (Narrative) (Details)</link:definition>

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        <link:definition>147 - Disclosure - Goodwill and Intangible Assets (Schedule of Goodwill) (Details)</link:definition>

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        <link:definition>148 - Disclosure - Goodwill and Intangible Assets (Schedule of Identifiable Intangible Assets) (Details)</link:definition>

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        <link:definition>149 - Disclosure - Goodwill and Intangible Assets (Schedule of Estimated Amortization Expense) (Details)</link:definition>

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        <link:definition>150 - Disclosure - U.S. Government Agreement, Joint Venture and Collaborations (Narrative) (Details)</link:definition>

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        <link:definition>151 - Disclosure - Other Financial Information (Narrative) (Details)</link:definition>

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        <link:definition>152 - Disclosure - Other Financial Information (Prepaid Expenses and Other Current Assets) (Details)</link:definition>

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        <link:definition>153 - Statement - Other Financial Information (Property and Equipment, Net) (Details)</link:definition>

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        <link:definition>154 - Disclosure - Other Financial Information (Accrued Expenses) (Details)</link:definition>

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        <link:definition>155 - Disclosure - Long-Term Debt (Narrative) (Details)</link:definition>

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        <link:definition>156 - Disclosure - Long-Term Debt (Notes Payable) (Details)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>

      <link:roleType roleURI="http://www.novavax.com/role/LongtermDebtNotesPayableParentheticalDetails" id="LongtermDebtNotesPayableParentheticalDetails">
        <link:definition>157 - Disclosure - Long-Term Debt (Notes Payable) (Parenthetical) (Details)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://www.novavax.com/role/LongtermDebtLoanAgreementsDetails" id="LongtermDebtLoanAgreementsDetails">
        <link:definition>158 - Disclosure - Long-Term Debt (Loan Agreements) (Details)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://www.novavax.com/role/StockholdersEquityNarrativeDetails" id="StockholdersEquityNarrativeDetails">
        <link:definition>159 - Disclosure - Stockholders&#39; Equity (Narrative) (Details)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://www.novavax.com/role/StockbasedCompensationNarrativeDetails" id="StockbasedCompensationNarrativeDetails">
        <link:definition>160 - Disclosure - Stock-Based Compensation (Narrative) (Details)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://www.novavax.com/role/StockbasedCompensationSummaryOfOptionActivityDetails" id="StockbasedCompensationSummaryOfOptionActivityDetails">
        <link:definition>161 - Disclosure - Stock-Based Compensation (Summary of Option Activity) (Details)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://www.novavax.com/role/StockbasedCompensationAssumptionsUsedInEstimationOfFairValueOfStockDetails" id="StockbasedCompensationAssumptionsUsedInEstimationOfFairValueOfStockDetails">
        <link:definition>162 - Disclosure - Stock-Based Compensation (Assumptions Used in Estimation of Fair Value of Stock) (Details)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://www.novavax.com/role/StockbasedCompensationSummaryOfRestrictedStockAwardsActivityDetails" id="StockbasedCompensationSummaryOfRestrictedStockAwardsActivityDetails">
        <link:definition>163 - Disclosure - Stock-Based Compensation (Summary of Restricted Stock Awards Activity) (Details)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://www.novavax.com/role/StockbasedCompensationStockbasedCompensationExpenseDetails" id="StockbasedCompensationStockbasedCompensationExpenseDetails">
        <link:definition>164 - Disclosure - Stock-Based Compensation (Stock-Based Compensation Expense) (Details)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://www.novavax.com/role/EmployeeBenefitsNarrativeDetails" id="EmployeeBenefitsNarrativeDetails">
        <link:definition>165 - Disclosure - Employee Benefits (Narrative) (Details)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://www.novavax.com/role/IncomeTaxesNarrativeDetails" id="IncomeTaxesNarrativeDetails">
        <link:definition>166 - Disclosure - Income Taxes (Narrative) (Details)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://www.novavax.com/role/IncomeTaxesLossFromOperationsBeforeIncomeTaxExpenseByJurisdictionDetails" id="IncomeTaxesLossFromOperationsBeforeIncomeTaxExpenseByJurisdictionDetails">
        <link:definition>167 - Disclosure - Income Taxes (loss from operations before income tax expense by jurisdiction) (Details)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://www.novavax.com/role/IncomeTaxesComponentsOfIncomeTaxProvisionBenefitDetails" id="IncomeTaxesComponentsOfIncomeTaxProvisionBenefitDetails">
        <link:definition>168 - Disclosure - Income Taxes (Components of The Income Tax Provision (Benefit) (Details)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://www.novavax.com/role/IncomeTaxesDeferredTaxAssetsLiabilitiesDetails" id="IncomeTaxesDeferredTaxAssetsLiabilitiesDetails">
        <link:definition>169 - Disclosure - Income Taxes (Deferred Tax Assets (Liabilities)) (Details)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>

      <link:roleType roleURI="http://www.novavax.com/role/IncomeTaxesTaxRatesDetails" id="IncomeTaxesTaxRatesDetails">
        <link:definition>170 - Disclosure - Income Taxes (Tax Rates) (Details)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://www.novavax.com/role/IncomeTaxesTaxReturnReportedFederalNetOperatingLossesAndTaxCreditsDetails" id="IncomeTaxesTaxReturnReportedFederalNetOperatingLossesAndTaxCreditsDetails">
        <link:definition>171 - Disclosure - Income Taxes (Tax Return Reported Federal Net Operating Losses and Tax Credits) (Details)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://www.novavax.com/role/IncomeTaxesReconciliationOfUnrecognizedTaxBenefitsDetails" id="IncomeTaxesReconciliationOfUnrecognizedTaxBenefitsDetails">
        <link:definition>172 - Disclosure - Income Taxes (Reconciliation of Unrecognized Tax Benefits) (Details)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://www.novavax.com/role/CommitmentsAndContingenciesNarrativeDetails" id="CommitmentsAndContingenciesNarrativeDetails">
        <link:definition>173 - Disclosure - Commitments and Contingencies (Narrative) (Details)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://www.novavax.com/role/CommitmentsAndContingenciesFutureMinimumRentalCommitmentsDetails" id="CommitmentsAndContingenciesFutureMinimumRentalCommitmentsDetails">
        <link:definition>174 - Disclosure - Commitments and Contingencies (Future Minimum Rental Commitments) (Details)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://www.novavax.com/role/RelatedPartyTransactionsNarrativeDetails" id="RelatedPartyTransactionsNarrativeDetails">
        <link:definition>175 - Disclosure - Related Party Transactions (Narrative) (Details)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://www.novavax.com/role/ConvertibleSeniorNotesNarrativeDetails" id="ConvertibleSeniorNotesNarrativeDetails">
        <link:definition>176 - Disclosure - Convertible Senior Notes (Narrative) (Details)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://www.novavax.com/role/QuarterlyFinancialInformationUnauditedDetails" id="QuarterlyFinancialInformationUnauditedDetails">
        <link:definition>177 - Disclosure - Quarterly Financial Information (Unaudited) (Details)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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  <element name="PurchaseObligationServicesReceived" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="nvax_PurchaseObligationServicesReceived" />

  <element name="ComputerSoftwareAndHardwareMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="nvax_ComputerSoftwareAndHardwareMember" />

  <element name="ResearchAndDevelopmentAccruals" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="nvax_ResearchAndDevelopmentAccruals" />

  <element name="AgreementsAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="nvax_AgreementsAxis" />

  <element name="AgreementsDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="nvax_AgreementsDomain" />

  <element name="CadilaMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="nvax_CadilaMember" />

  <element name="BusinessAcquisitionPercentageOfVotingInterestsAcquiredDuringPeriod" type="num:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="nvax_BusinessAcquisitionPercentageOfVotingInterestsAcquiredDuringPeriod" />

  <element name="EquipmentLoanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="nvax_EquipmentLoanMember" />

  <element name="BankLoansMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="nvax_BankLoansMember" />

  <element name="LoanAgreementFutureMinimumPaymentsNextRollingTwelveMonths" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="nvax_LoanAgreementFutureMinimumPaymentsNextRollingTwelveMonths" />

  <element name="LoanAgreementFutureMinimumPaymentsDue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="nvax_LoanAgreementFutureMinimumPaymentsDue" />

  <element name="DebtinstrumentTermExtended" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="nvax_DebtinstrumentTermExtended" />

  <element name="NovavaxAbMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="nvax_NovavaxAbMember" />

  <element name="AvailableForSaleSecuritiesNumberOfSecuritiesOwned" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="nvax_AvailableForSaleSecuritiesNumberOfSecuritiesOwned" />

  <element name="AvailableForSaleSecuritiesNumberOfSecuritiesOwnedUnrealizedLosses" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="nvax_AvailableForSaleSecuritiesNumberOfSecuritiesOwnedUnrealizedLosses" />

  <element name="SummaryOfSignificantAccountingPoliciesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="nvax_SummaryOfSignificantAccountingPoliciesLineItems" />

  <element name="TwoThousandFifteenStockIncentivePlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="nvax_TwoThousandFifteenStockIncentivePlanMember" />

  <element name="IncreaseInFundingForRecoveryOfAdditionalCostsUnderContract" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="nvax_IncreaseInFundingForRecoveryOfAdditionalCostsUnderContract" />

  <element name="BillMelindaGatesFoundationMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="nvax_BillMelindaGatesFoundationMember" />

  <element name="GrantAgreement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="nvax_GrantAgreement" />

  <element name="AccruedMilestonePayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="nvax_AccruedMilestonePayment" />

  <element name="NoticePeriodRequiredForTerminationOfLicenseAgreement" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="nvax_NoticePeriodRequiredForTerminationOfLicenseAgreement" />

  <element name="AggregatePaymentsMadePerLicenseAgreement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="nvax_AggregatePaymentsMadePerLicenseAgreement" />

  <element name="IncreaseInLicenseMaintenanceFees" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="nvax_IncreaseInLicenseMaintenanceFees" />

  <element name="IncreaseInMilestonePayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="nvax_IncreaseInMilestonePayment" />

  <element name="StockPriceConversionPremiumBasedUpon" type="num:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="nvax_StockPriceConversionPremiumBasedUpon" />

  <element name="PaymentsForCappedCallTransactions" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="nvax_PaymentsForCappedCallTransactions" />

  <element name="PercentageOfConversionPremium" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="nvax_PercentageOfConversionPremium" />

  <element name="CapPriceOnCallTransactions" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="nvax_CapPriceOnCallTransactions" />

  <element name="ConvertibleSeniorNotesTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="nvax_ConvertibleSeniorNotesTextBlock" />

  <element name="PercentageOfConversionPremiumWithCallTransactions" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="nvax_PercentageOfConversionPremiumWithCallTransactions" />
</schema>

