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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2015

Income Tax Disclosure [Abstract]

Company’s loss from operations before income tax expense by jurisdiction

The Company’s loss from operations before income tax expense by jurisdiction are as follows (in thousands):

		2015			2014			2013
Domestic		$	(150,227)		$	(76,742)		$	(48,691)
Foreign			(6,710)			(6,205)			(3,292)
Total net loss		$	(156,937)		$	(82,947)		$	(51,983)

Components of The Income Tax Provision (Benefit)

The components of the income tax provision are as follows (in thousands):

		2015			2014			2013
Current U.S.		$	—		$	—		$	—
Current foreign			—			—			25
Deferred			—			—			—
Net provision		$	—		$	—		$	25

Deferred Tax Assets (Liabilities)

Deferred tax assets (liabilities) consist of the following at December 31 (in thousands):

		2015			2014
Net operating losses U.S.		$	203,284		$	148,451
Net operating losses foreign			8,360			6,535
Research tax credits			16,491			11,068
Other			12,903			9,963
Total deferred tax assets			241,038			176,017
Intangibles			(2,415)			(2,773)
Other			(1,767)			(321)
Total deferred tax liabilities			(4,182)			(3,094)
Net deferred tax assets			236,856			172,923
Less valuation allowance			(236,856)			(172,923)
Deferred tax assets, net		$	—		$	—

Tax Rate Differences

The differences between the U.S. federal statutory tax rate and the Company’s effective tax rate are as follows:

		2015			2014			2013
Statutory federal tax rate			(34)	%		(34)	%		(34)	%
State income taxes, net of federal benefit			(3)	%		(3)	%		(3)	%
Research and development and other tax credits			(3)	%		(2)	%		(7)	%
Expiration of net operating losses			0	%		0	%		0	%
Release of FIN 48 liability			(2)	%		0	%		0	%
Other			1	%		2	%		3	%
Change in valuation allowance			41	%		37	%		41	%
			0	%		0	%		0	%

Tax Return Reported Federal Net Operating Losses and Tax Credits Available

As of December 31, 2015, the Company had tax return reported federal net operating losses and tax credits available as follows (in thousands):

		Amount
Federal net operating losses expiring through the year 2035		$	551,433
Foreign net operating losses (no expiration)			38,001
Research tax credits expiring through the year 2035			16,397
Alternative-minimum tax credit (no expiration)			94

Reconciliation of Unrecognized Tax Benefits

Tabular Reconciliation of Unrecognized Tax Benefits (in thousands):

		Amount
Unrecognized tax benefits as of January 1, 2014		$	4,801
Gross increases — tax positions in prior period			—
Gross decreases — tax positions in prior period			—
Gross increases — current-period tax positions			—
Increases (decreases) from settlements			—
Unrecognized tax benefits as of December 31, 2014		$	4,801
Gross increases — tax positions in prior period			—
Gross decreases — tax positions in prior period			4,587
Gross increases — current-period tax positions			—
Increases (decreases) from settlements			—
Unrecognized tax benefits as of December 31, 2015		$	214

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