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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2016 | Sep. 30, 2015
Operating Activities: |  |
Net loss | $ (222,857) | $ (78,131)
Reconciliation of net loss to net cash used in operating activities: |  |
Depreciation and amortization | 6,287 | 4,347
Amortization of net premiums on marketable securities | 263 | 955
Amortization of debt issuance costs | 949 | 0
Deferred rent | 402 | (554)
Lease incentives received | 1,963 | 0
Non-cash stock-based compensation | 15,380 | 9,278
Other | 301 | 140
Changes in operating assets and liabilities: |  |
Restricted cash | 4,980 | 297
Accounts receivable | 1,716 | 6,466
Prepaid expenses and other assets | (2,478) | (6,536)
Accounts payable and accrued expenses | 6,396 | (7,706)
Deferred revenue | (5,980) | 105
Other liabilities | (1,541) | 0
Net cash used in operating activities | (194,219) | (71,339)
Investing Activities: |  |
Capital expenditures | (15,009) | (13,648)
Proceeds from maturities of marketable securities | 284,871 | 137,107
Purchases of marketable securities | (327,750) | (154,288)
Net cash used in investing activities | (57,888) | (30,829)
Financing Activities: |  |
Principal payments on capital leases | (53) | (49)
Principal payments on notes payable | (350) | (458)
Changes in restricted cash | (819) | (126)
Proceeds from issuance of convertible notes | 325,000 | 0
Payments of costs related to issuance of convertible notes | (9,966) | 0
Payments for capped call transactions and costs | (38,521) | 0
Net proceeds from sales of common stock | 0 | 204,275
Proceeds from the exercise of stock options and employee stock purchases | 3,793 | 4,440
Net cash provided by financing activities | 279,084 | 208,082
Effect of exchange rate on cash and cash equivalents | (137) | (105)
Net increase in cash and cash equivalents | 26,840 | 105,809
Cash and cash equivalents at beginning of period | 93,108 | 32,335
Cash and cash equivalents at end of period | 119,948 | 138,144
Supplemental disclosure of non-cash activities: |  |
Property and equipment purchases included in accounts payable and accrued expenses | 2,060 | 2,390
Supplemental disclosure of cash flow information: |  |
Cash payments of interest | $ 6,186 | $ 79

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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3255-108585 + Details
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- Definition Amount of cash inflow (outflow) from long-term debt supported by a written promise to pay an obligation. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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- Definition The net cash inflow or outflow from cash and cash items that are not available for withdrawal or usage. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3255-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3291-108585 + Details
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- Definition The cash inflow associated with the sale or maturity (principal being due) of securities not classified as either held-to-maturity securities or trading securities which are classified as available-for-sale securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3179-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=66010992&loc=d3e26853-111562 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 + Details
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- Definition The cash inflow associated with the amount received from holders exercising their stock options. This item inherently excludes any excess tax benefit, which the entity may have realized and reported separately. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (j) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3255-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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- Definition The cash outflow for the obligation for a lease meeting the criteria for capitalization (with maturities exceeding one year or beyond the operating cycle of the entity, if longer). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3291-108585 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 + Details
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- References No definition available. + Details
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