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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2016
Income Tax Disclosure [Abstract] |
Company’s loss from operations before income tax expense by jurisdiction | The Company’s loss from operations before income tax expense by jurisdiction for the year ended December 31 are as follows (in thousands):
|  | 2016 |  | 2015 |  | 2014 |
Domestic |  | $ | (273,134) |  | $ | (150,227) |  | $ | (76,742) |
Foreign |  |  | (6,832) |  |  | (6,710) |  |  | (6,205) |
Total net loss |  | $ | (279,966) |  | $ | (156,937) |  | $ | (82,947) |
Deferred Tax Assets (Liabilities) | Deferred tax assets (liabilities) consist of the following at December 31 (in thousands):
|  | 2016 |  | 2015 |
Net operating losses U.S. |  | $ | 286,619 |  | $ | 203,284 |
Net operating losses foreign |  |  | 9,011 |  |  | 8,360 |
Research tax credits |  |  | 23,260 |  |  | 16,491 |
Deferred revenue |  |  | 10,121 |  |  | 922 |
Original discount interest |  |  | 12,445 |  |  | — |
Other |  |  | 17,981 |  |  | 11,981 |
Total deferred tax assets |  |  | 359,437 |  |  | 241,038 |
Intangibles |  |  | (2,090) |  |  | (2,415) |
Other |  |  | (2,817) |  |  | (1,767) |
Total deferred tax liabilities |  |  | (4,907) |  |  | (4,182) |
Net deferred tax assets |  |  | 354,530 |  |  | 236,856 |
Less valuation allowance |  |  | (354,530) |  |  | (236,856) |
Deferred tax assets, net |  | $ | — |  | $ | — |
Tax Rate Differences | The differences between the U.S. federal statutory tax rate and the Company’s effective tax rate are as follows:
|  | 2016 |  | 2015 |  | 2014 |
Statutory federal tax rate |  |  | (34) | % |  | (34) | % |  | (34) | %
State income taxes, net of federal benefit |  |  | (3) | % |  | (3) | % |  | (3) | %
Research and development and other tax credits |  |  | (2) | % |  | (3) | % |  | (2) | %
Release of FIN 48 liability |  |  | 0 | % |  | (2) | % |  | 0 | %
Other |  |  | 2 | % |  | 1 | % |  | 2 | %
Change in valuation allowance |  |  | 37 | % |  | 41 | % |  | 37 | %
|  |  | 0 | % |  | 0 | % |  | 0 | %
Tax Return Reported Federal Net Operating Losses and Tax Credits Available | As of December 31, 2016, the Company had tax return reported federal net operating losses and tax credits available as follows (in thousands):
|  | Amount |
Federal net operating losses expiring through the year 2036 |  | $ | 781,019 |
Foreign net operating losses (no expiration) |  |  | 40,957 |
Research tax credits expiring through the year 2036 |  |  | 23,166 |
Alternative-minimum tax credit (no expiration) |  |  | 94 |
Reconciliation of Unrecognized Tax Benefits | Tabular Reconciliation of Unrecognized Tax Benefits (in thousands):
|  | Amount |
Unrecognized tax benefits as of January 1, 2015 |  | $ | 4,801 |
Gross increases — tax positions in prior period |  |  | — |
Gross decreases — tax positions in prior period |  |  | 4,587 |
Gross increases — current-period tax positions |  |  | — |
Increases (decreases) from settlements |  |  | — |
Unrecognized tax benefits as of December 31, 2015 |  | $ | 214 |
Gross increases — tax positions in prior period |  |  | — |
Gross decreases — tax positions in prior period |  |  | 214 |
Gross increases — current-period tax positions |  |  | — |
Increases (decreases) from settlements |  |  | — |
Unrecognized tax benefits as of December 31, 2016 |  | $ | — |

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- Definition Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=65882285&loc=d3e32687-109319 + Details
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