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Commitments and Contingencies (Narrative) (Details) | 1 Months Ended | 12 Months Ended |
--- | --- | --- | ---
May 31, 2016 USD ($) ft² | Dec. 31, 2016 USD ($) | Dec. 31, 2015 USD ($) | Dec. 31, 2014 USD ($) | Sep. 30, 2015 USD ($)
Rent expense |  | $ 7,000,000 | $ 4,200,000 | $ 3,600,000 |
Accrued milestone payment associated with the first Phase 3 clinical trial |  |  |  |  | $ 3,000,000
Notice period required for termination of license agreement |  | 90 days |  |  |
Aggregate amount of payments made under license agreement |  | $ 7,600,000 |  |  |
Gaithersburg, Maryland [Member] |  |  |  |  |
Tenant Improvement Allowance | $ 9,600,000 | 0 |  |  |
Rental Square Footage of Building | ft² | 150,000 |  |  |  |
Facility Lease Term | 2030 |  |  |  |
Rockville, Maryland [Member] |  |  |  |  |
Facility Lease Term | 2020 |  |  |  |
Uppsala, Sweden [Member] |  |  |  |  |
Facility Lease Term | 2026 |  |  |  |
Maximum [Member] |  |  |  |  |
Increase In License Maintenance Fees |  | 300,000 |  |  |
Increase In Milestone Payment |  | 15,000,000 |  |  |
Minimum [Member] |  |  |  |  |
Increase In License Maintenance Fees |  | 200,000 |  |  |
Increase In Milestone Payment |  | $ 14,000,000 |  |  |

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