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CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Revenue: |  |  |
Government contracts | $ 2,184 | $ 33,344 | $ 26,213
Research and development collaborations | 13,169 | 2,906 | 4,446
Total revenue | 15,353 | 36,250 | 30,659
Expenses: |  |  |
Research and development | 237,939 | 162,644 | 94,422
General and administrative | 46,527 | 30,842 | 19,928
Total expenses | 284,466 | 193,486 | 114,350
Loss from operations | (269,113) | (157,236) | (83,691)
Other income (expense): |  |  |
Investment income | 2,143 | 660 | 286
Interest expense | (12,965) | (241) | (157)
Other income | (31) | (120) | 0
Realized gains on marketable securities | 0 | 0 | 615
Net loss | $ (279,966) | $ (156,937) | $ (82,947)
Basic and diluted net loss per share | $ (1.03) | $ (0.60) | $ (0.37)
Basic and diluted weighted average number of common shares outstanding | 270,802 | 262,248 | 225,848

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