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Stock-Based Compensation - Compensation Expense (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2022 | Jun. 30, 2021 | Jun. 30, 2022 | Jun. 30, 2021
Compensation expense: |  |  |  |
Total stock-based compensation expense | $ 38,048 | $ 53,123 | $ 70,981 | $ 106,183
Research and development |  |  |  |
Compensation expense: |  |  |  |
Total stock-based compensation expense | 19,695 | 24,779 | 36,582 | 48,569
General and administrative |  |  |  |
Compensation expense: |  |  |  |
Total stock-based compensation expense | $ 18,353 | $ 28,344 | $ 34,399 | $ 57,614

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- Definition Amount of expense for award under share-based payment arrangement. Excludes amount capitalized. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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