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Intangible Assets and Goodwill (Tables)
 6 Months Ended
Jun. 30, 2022
Goodwill and Intangible Assets Disclosure [Abstract]  
Schedule of identifiable intangible assets
Purchased intangible assets consisted of the following (in thousands):
June 30, 2022December 31, 2021
Gross
Carrying
Amount		Accumulated 
Amortization		Intangible
Assets, Net		Gross
Carrying
Amount		Accumulated 
Amortization		Intangible
Assets, Net
Finite-lived intangible assets:
Proprietary adjuvant technology$7,278 $(3,245)$4,033 $8,239 $(3,469)$4,770 
Collaboration agreements3,286 (3,286)— 3,722 (3,722)— 
Total identifiable intangible assets$10,564 $(6,531)$4,033 $11,961 $(7,191)$4,770 
Schedule of estimated amortization expense Estimated amortization expense for existing intangible assets for the remainder of 2022 and for each of the five succeeding years ending December 31 will be as follows (in thousands):
YearAmount
2022 (remainder)$182 
2023364 
2024364 
2025364 
2026364 
2027364 
Schedule of goodwill
The change in the carrying amounts of goodwill for the six months ended June 30, 2022 was as follows (in thousands):
Amount
Balance at December 31, 2021$131,479 
Currency translation adjustments(8,012)
Balance at June 30, 2022$123,467